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Effectiveness and safety of vitamin D in relation to bone health.
TLDR
The largest body of evidence on vitamin D status and bone health was in older adults with a lack of studies in premenopausal women and infants, children and adolescents, and there was fair evidence of an association between low circulating 25(OH)D concentrations and established rickets.
Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions
TLDR
This Guide presents issues key to the development of Comparative Effectiveness Reviews and describes recommended approaches for addressing difficult, frequently encountered methodological issues.
Universal school-based prevention programs for alcohol misuse in young people.
TLDR
Current evidence suggests that certain generic psychosocial and developmental prevention programs can be effective and could be considered as policy and practice options.
Universal family-based prevention programs for alcohol misuse in young people.
TLDR
The effects of family-based prevention interventions are small but generally consistent and also persistent into the medium- to longer-term, as well as gender-specific, focusing on young females.
Oral Phosphodiesterase-5 Inhibitors and Hormonal Treatments for Erectile Dysfunction: A Systematic Review and Meta-analysis
TLDR
The aims of the review were to determine the relative benefits and harms of oral PDE-5 inhibitors and hormonal treatments of ED, including the effect of patient characteristics and comorbid conditions on the likelihood of treatment success and the clinical value of hormonal blood testing for identifying treatable causes of ED (for example, hypogonadism) and improving its outcomes.
A Systematic Review and Meta-Analysis of Efficacy, Cost-Effectiveness, and Safety of Selected Complementary and Alternative Medicine for Neck and Low-Back Pain
TLDR
CAM treatments were significantly more efficacious than no treatment, placebo, physical therapy, or usual care in reducing pain immediately or at short-term after treatment, and none of the CAM treatments was shown systematically as superior to one another.
Diagnosis and management of febrile infants (0-3 months).
TLDR
Overall, the focus of the literature has been on ruling out SBI, and most of the criteria/protocols demonstrated high negative predictive values and low positive predictive values for correctly predicting the absence or presence of SBI.
Universal multi-component prevention programs for alcohol misuse in young people.
TLDR
There is some evidence that multi-component interventions for alcohol misuse prevention in young people can be effective, but there is little evidence that interventions with multiple components are more effective than interventions with single components.
Efficacy of food fortification on serum 25-hydroxyvitamin D concentrations: systematic review.
TLDR
Most trials were small in size and inadequately reported allocation concealment, but results showed that vitamin D-fortified foods improved vitamin D status in adults.
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