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Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
- B. Reubinoff, M. Pera, C. Fong, A. Trounson, A. Bongso
- Biology, MedicineNature Biotechnology
- 1 April 2000
The derivation of pluripotent embryonic stem (ES) cells from human blastocysts is described, providing a model to study early human embryology, an investigational tool for discovery of novel growth factors and medicines, and a potential source of cells for use in transplantation therapy.
Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo
Cryopreservation procedures that allow a high survival rate of four- and eight-cell human embryos and the establishment of a pregnancy following the freezing and storage of an eight- cell embryo for 4 months in liquid nitrogen are reported.
New method for culture of zona‐included or zona‐free embryos: The Well of the Well (WOW) system
- G. Vajta, T. Peura, +4 authors H. Callesen
- Biology, MedicineMolecular reproduction and development
- 1 March 2000
Apart from its theoretical value in revealing the role of different factors influencing embryo development in vitro, the WOW system may have immediate practical consequences in certain areas of mammalian embryo production.
In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients.
Immature oocyte recovery could be developed as a new method for the treatment of women with infertility due to PCO because the oocytes of these patients retain their maturational and developmental competence.
Birth following vitrification of a small number of human oocytes: case report.
- L. Kuleshova, L. Gianaroli, C. Magli, A. Ferraretti, A. Trounson
- Biology, MedicineHuman reproduction
- 1 December 1999
The birth of a healthy baby girl at 37 weeks gestation to a 47 year old recipient, after vitrification of mature oocytes from four in-vitro fertilization (IVF) patients, is encouraging for further research to explore the potential benefits of vitrification for the cryopreservation of human oocytes.
Effective cryopreservation of human embryonic stem cells by the open pulled straw vitrification method.
Vitrified human ES cells were cultivated for prolonged periods and retained the properties of pluripotent cells, including a normal karyotype, expression of the transcription factor Oct-4 and surface markers that are characteristic tohuman ES cells.
Fundamental cryobiology of mammalian oocytes and ovarian tissue.
Some of the advances in this area are described and the relative merits and limitations of several currently available egg and ovarian tissue cryopreservation procedures are outlined.
Stem Cell Therapies in Clinical Trials: Progress and Challenges.
Clinical investigations using stem cell products in regenerative medicine are addressing a wide spectrum of conditions using a variety of stem cell types and applications are progressing in trials, some with early benefits to patients.
Testicular Cell Conditioned Medium Supports Differentiation of Embryonic Stem Cells into Ovarian Structures Containing Oocytes
The production of oocytes using this method is repeatable and reliable and may be applicable to other mammalian species, including the human.
Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
- M. Pera, Jessica Andrade, +5 authors C. Mummery
- Biology, MedicineJournal of Cell Science
- 1 March 2004
It is shown that endogenous signaling by bone morphogenetic protein-2 controls the differentiation of embryonic stem cells into this lineage, and that the conservation of developmental mechanisms at the cellular level can be exploited in this system to provide a facile route for the generation of neural precursors from pluripotent cells.