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Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse
The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlyingExpand
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Target-Dependent Use of Coreleased Inhibitory Transmitters at Central Synapses
Corelease of GABA and glycine by mixed neurons is a prevalent mode of inhibitory transmission in the vertebrate hindbrain. However, little is known of the functional organization of mixed inhibitoryExpand
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Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
Fine control of neuronal activity is crucial to rapidly adjust to subtle changes of the environment. This fine tuning was thought to be purely neuronal until the discovery that astrocytes are activeExpand
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Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix
Presynaptic terminals are specialized for mediating rapid fusion of synaptic vesicles (SVs) after calcium influx. The regulated trafficking of SVs likely results from a highly organized cytomatrix.Expand
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Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking
Semiconductor quantum dots (QDs) are nanometer-sized fluorescent probes suitable for advanced biological imaging. We used QDs to track individual glycine receptors (GlyRs) and analyze their lateralExpand
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GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
Controlling the number of functional γ-aminobutyric acid A (GABAA) receptors in neuronal membranes is a crucial factor for the efficacy of inhibitory neurotransmission. Here we describe the directExpand
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A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
A growing number of long nuclear‐retained non‐coding RNAs (ncRNAs) have recently been described. However, few functions have been elucidated for these ncRNAs. Here, we have characterized the functionExpand
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Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5
Soluble oligomers of amyloid beta (Abeta) play a role in the memory impairment characteristic of Alzheimer's disease. Acting as pathogenic ligands, Abeta oligomers bind to particular synapses andExpand
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Presence of the vesicular inhibitory amino acid transporter in GABAergic and glycinergic synaptic terminal boutons.
The characterization of the Caenorhabditis elegans unc-47 gene recently allowed the identification of a mammalian (gamma)-amino butyric acid (GABA) transporter, presumed to be located in the synapticExpand
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Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which is caused by a polyglutamine repeat in theExpand
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