• Publications
  • Influence
Evidence of an inhibitory restraint of seizure activity in humans
TLDR
There is a sharp delineation between areas showing intense, hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing, which has important implications for how to localize seizure activity and map its spread. Expand
Modular Propagation of Epileptiform Activity: Evidence for an Inhibitory Veto in Neocortex
TLDR
It is proposed that the interneurons that supply the vetoing inhibition define these modular circuit territories and epileptiform events progress in intermittent steps across the cortical network. Expand
Feedforward Inhibition Contributes to the Control of Epileptiform Propagation Speed
TLDR
It is proposed that the speed of propagation is set by the extent of the recruitment steps, which in turn is setBy how successfully the feedforward inhibitory restraint contains the excitatory drive, which could account for the wide range of propagation velocities of epileptiform events observed in vitro and in vivo. Expand
Ictal high frequency oscillations distinguish two types of seizure territories in humans.
TLDR
An efficient measure to detect delayed-onset, sustained ictal high frequency oscillations based on cross-frequency coupling between high gamma amplitude and the low-frequency ictAL rhythm is developed and revealed a surprisingly small and slowly spreading seizure core surrounded by a far larger penumbral territory. Expand
Spatial characterization of interictal high frequency oscillations in epileptic neocortex
TLDR
The spatial extent, classification and distribution of HFOs using a dense 4 × 4 mm2 two dimensional microelectrode array implanted in the neocortex of four patients undergoing epilepsy surgery are investigated, finding that fast ripples may be markers of a secondary local response. Expand
The Direct Relationship between Inhibitory Currents and Local Field Potentials
  • A. Trevelyan
  • Psychology, Medicine
  • The Journal of Neuroscience
  • 2 December 2009
TLDR
It is shown that at these times, isolated inhibitory currents from single pyramidal cells have a similarity to the extracellular signal that significantly exceeds chance, which suggests that a significant component of HFOs reflects the last act of defiance in the face of an advancing ictal event. Expand
Quantal Analysis Reveals a Functional Correlation between Presynaptic and Postsynaptic Efficacy in Excitatory Connections from Rat Neocortex
TLDR
Recording from synaptically coupled pairs of pyramidal neurons in rat visual cortex suggested that during development of cortical connections presynaptic and postsynaptic strengths are dependently scaled. Expand
Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity
TLDR
Higher levels of neurogenesis can be achieved in aged mice by ectopically expressing proliferator‐activated receptor gamma coactivator 1 alpha (PGC1α), a factor that increases cellular aerobic capacity by promoting mitochondrial biogenesis and metabolic gene transcription. Expand
Opportunities for improving animal welfare in rodent models of epilepsy and seizures
TLDR
This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. Expand
The Source of Afterdischarge Activity in Neocortical Tonic–Clonic Epilepsy
TLDR
The data suggest a complex view of seizures in which the ictal event and its constituent discharges originate from distinct locations, and there is not a single source of afterdischarge activity: rather, the source is continuously changing. Expand
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