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Sequence periodicities in chicken nucleosome core DNA.
The rotational positioning of DNA about the histone octamer appears to be determined by certain sequence-dependent modulations of DNA structure, and it is observed that long runs of homopolymer (dA) X (dT) prefer to occupy the ends of core DNA, five to six turns away from the dyad. Expand
The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster.
The cloning, expression and phenotypic characterisation of repo is described, a gene from Drosophila melanogaster that is essential for the differentiation and maintenance of glia function that is also observed in the locust Schistocerca gregaria and is thus evolutionarily conserved. Expand
HMG1 and 2, and related 'architectural' DNA-binding proteins.
The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins, bend DNA and bind preferentially to distorted DNA structures and might be targeted to particular DNA sites in chromatin by either protein-protein interactions or recognition of specific DNA structures. Expand
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
The findings suggest that the Gcn5p bromodomain may discriminate between different acetylated lysine residues depending on the context in which they are displayed. Expand
High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes
- Benjamin Lang, N. Blot, +10 authors A. Travers
- Biology, Medicine
- Nucleic acids research
- 1 September 2007
H-NS silences extensive regions of the bacterial chromosome by binding first to nucleating high-affinity sites and then spreading along AT-rich DNA, thereby providing a coherent framework that unifies studies on the H-NS protein and a concrete molecular basis for the genetic control of H- NS transcriptional silencing. Expand
DNA supercoiling — a global transcriptional regulator for enterobacterial growth?
It is argued that regulation of DNA supercoiling provides a coherent explanation for the main modes of transcriptional control — stringent control, growth-rate control and growth-phase control — during the normal growth of Escherichia coli. Expand
Assessment of acrosome and nuclear abnormalities in human spermatozoa with large vacuoles.
In the selected teratozoospermic population, aneuploidy and chromatin condensation defects were the main alterations observed in SLV, and a global impairment of the spermatogenesis process is proposed. Expand
H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencing
- E. Bouffartigues, M. Buckle, C. Badaut, A. Travers, S. Rimsky
- Biology, Medicine
- Nature Structural &Molecular Biology
- 15 April 2007
This work shows that the negative regulatory element of the supercoiling-sensitive Escherichia coliproU gene contains two identical high-affinity binding sites for H-NS, and demonstrates that the high-Affinity sites nucleate cooperative binding and establish a nucleoprotein structure required for silencing. Expand
DNA bending and its relation to nucleosome positioning.
It is shown that certain sequence-dependent modulations in structure appear to determine the rotational positioning of DNA about the nucleosome. Expand
Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes.
- K. Giesen, T. Hummel, A. Stollewerk, S. Harrison, A. Travers, C. Klämbt
- Biology, Medicine
- 15 June 1997
A novel component required for all CNS glia development is described, the tramtrack gene, which encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non-neuronal CNS cells. Expand