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Sequence periodicities in chicken nucleosome core DNA.
The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster.
The cloning, expression and phenotypic characterisation of repo is described, a gene from Drosophila melanogaster that is essential for the differentiation and maintenance of glia function that is also observed in the locust Schistocerca gregaria and is thus evolutionarily conserved.
HMG1 and 2, and related 'architectural' DNA-binding proteins.
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
The findings suggest that the Gcn5p bromodomain may discriminate between different acetylated lysine residues depending on the context in which they are displayed.
High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes
H-NS silences extensive regions of the bacterial chromosome by binding first to nucleating high-affinity sites and then spreading along AT-rich DNA, thereby providing a coherent framework that unifies studies on the H-NS protein and a concrete molecular basis for the genetic control of H- NS transcriptional silencing.
DNA supercoiling — a global transcriptional regulator for enterobacterial growth?
It is argued that regulation of DNA supercoiling provides a coherent explanation for the main modes of transcriptional control — stringent control, growth-rate control and growth-phase control — during the normal growth of Escherichia coli.
Assessment of acrosome and nuclear abnormalities in human spermatozoa with large vacuoles.
In the selected teratozoospermic population, aneuploidy and chromatin condensation defects were the main alterations observed in SLV, and a global impairment of the spermatogenesis process is proposed.
H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencing
- E. Bouffartigues, M. Buckle, C. Badaut, A. Travers, S. Rimsky
- BiologyNature Structural &Molecular Biology
- 15 April 2007
This work shows that the negative regulatory element of the supercoiling-sensitive Escherichia coliproU gene contains two identical high-affinity binding sites for H-NS, and demonstrates that the high-Affinity sites nucleate cooperative binding and establish a nucleoprotein structure required for silencing.
DNA structure and function
It is argued that, in addition to its coding function, the ability of DNA, unlike RNA, to adopt a B‐DNA structure confers advantages both for information accessibility and for packaging.