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SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA‐damage‐response proteins
Mutational analyses of a number of SCD‐containing proteins indicate that multisite phosphorylation of SQ/TQ motifs is required for normal DNA‐damage responses, most commonly by mediating protein–protein interactions in the formation of DNA‐ damage‐induced complexes.
Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy
A synthesis of this emerging field is provided, proposing that mitochondrial function in membrane lipid homeostasis is the common denominator underlying the observed effects of mitochondria in drug tolerance (both sensitivity and resistance).
Yeast Gal4: a transcriptional paradigm revisited
This review provides an updated account of Gal4 function, including data from new technologies that have been recently applied to the study of the GAL network.
The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages
The data provide a new model for how the interplay between fungal morphogenesis and activation of a host cell death pathway mediates macrophage killing by C. albicans hyphae and suggest that the defects of the Mediator mutants in causing macrophages death are caused, at least in part, by reduced activation of pyroptosis.
Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans
An antifungal defensin, NaD1, with activity against the major human pathogen Candida albicans is described, the mechanism of killing is characterized, and inhibition of the HOG pathway holds promise as a broad strategy for increasing the activity of antimicrobial peptides against C.Albicans.
A global virulence regulator in Acinetobacter baumannii and its control of the phenylacetic acid catabolic pathway.
This study characterizes a global virulence regulator, which may provide an alternate therapeutic target, in one of the most troublesome hospital-acquired pathogens.
Interorganellar Communication
Yeast petite mutants lacking mitochondrial DNA induce genes coding for mitochondrial proteins, enzymes of the glycolytic pathway and of the citric acid cycle, cell wall components, membrane transporters, and genes normally induced by nutrient deprivation and a variety of stresses, consistent with the observed induction of genes related to cell stress.