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Modulation of Remifentanil-Induced Postinfusion Hyperalgesia by Propofol
TLDR
The results suggest clinically relevant interactions of propofol and remifentanil in humans, since prop ofol led to a delay and a weakening of remifENTanil-induced postinfusion anti-analgesia in humans.
Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by Parecoxib in Humans
TLDR
The results confirm clinically relevant interaction of &mgr; opioids and prostaglandins in humans and suggest adequate timing seems to be of particular importance for the antihyperalgesic effect of cyclooxygenase-2 inhibitors.
Beyond the Van Der Waals loop: What can be learned from simulating Lennard-Jones fluids inside the region of phase coexistence
As a rule, mean-field theories applied to a fluid that can undergo a transition from saturated vapor at density ρυ to a liquid at density ρl yield a van der Waals loop. For example, isotherms of the
Numerical approaches to determine the interface tension of curved interfaces from free energy calculations.
TLDR
It is found that the conventional theory of nucleation, where the interface tension of planar liquid-vapor interfaces is used to predict nucleation barriers, leads to a significant overestimation, and this failure is particularly large for bubbles.
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.
TLDR
The electrical hyperalgesia model can serve to predict analgesic efficacy in early human development and investigate the mechanism of action.
Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.
TLDR
A semisynthesis of homogeneous glycoforms of IL-6 was established by sequential native chemical ligation using glycopeptide hydrazides, which showed full bioactivity after efficient refolding and purification.
Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain model.
Ultralow-frequency elastic response in KMn1-xCaxF3
We present novel low-frequency (0.1 Hz–50 Hz) measurements of the complex elastic susceptibility of KMn 1 − x Ca x F3 (x = 0, 0.003, 0.018). An ultraslow relaxational process in pure KMnF3 just below
Fragment condensation of C-terminal pseudoproline peptides without racemization on the solid phase.
TLDR
A convergent fragment-condensation method, which uses segments having a C-terminal pseudoproline that prevents racemization and can be used to overcome the size limitations in the stepwise synthesis of peptides and glycopeptides, is reported.
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