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Electrophysiological, behavioral, and chemical evidence for a noncholinergic, stereospecific site for nicotine in rat brain
The behavioral response consisted of a prostration‐immobilization syndrome following the injection of 1−10 μg of nicotine into the region of the lateral or third transmitters and their antagonists, and a number of other psychotropic drugs were ineffective in either enhancing or antagonizing the action of nicotine. Expand
Characterization of azidobenzamidines as photoaffinity labels for trypsin.
These studies provide a basis for the use of azidobenzamidines as photoaffinity analogs of lysine and arginine side chains and may provide a sensitive tool for probing conformational changes in inhibitor binding sites. Expand
In vitro system for detecting nongenotoxic carcinogens
The experiments described here suggest that the carcinogenic role of some chemicals may be attributed to their ability to modify the biochemical pathways of drug metabolism, by enhancing or inhibiting the activity of various enzymes. Expand
Insulin synthesis by recombination of A and B chains: a highly efficient method.
Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model.
The murine malaria parasite, P. berghei, served as a micronucleus model and facilitated the development of an accurate flow cytometry based scoring method, leading to high resolution of the rare cells. Expand
The application of high-voltage thin-layer electrophoresis to the separation of peptides, nucleotides, and proteins☆
Abstract The migration of large peptides, nucleotides and proteins during thin-layer electrophoresis has been studied using cellulose and Pevikon C-870 (PVC), a copolymer of polyvinyl chloride andExpand