• Publications
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Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell migration byExpand
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Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
Tolerating Tumors Successful tumor growth depends on the ability of the tumor to escape detection by the immune system. Human cancers that express the chemokine receptor CCR7 are associated withExpand
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Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-Engineered Lymph Node Microenvironment1
In the paracortex of the lymph node (LN), T zone fibroblastic reticular cells (TRCs) orchestrate an immune response by guiding lymphocyte migration both physically, by creating three-dimensional (3D)Expand
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3D collagen cultures under well‐defined dynamic strain: A novel strain device with a porous elastomeric support
The field of mechanobiology has grown tremendously in the past few decades, and it is now well accepted that dynamic stresses and strains can impact cell and tissue organization, cell–cell andExpand
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Device design and materials optimization of conformal coating for islets of Langerhans
Significance Cell encapsulation with biocompatible and permeable hydrogels may allow transplantation without immunosuppression. As an alternative to standard microencapsulation approaches that createExpand
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Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival.
By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particlesExpand
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Effects of Composition of Alginate-Polyethylene Glycol Microcapsules and Transplant Site on Encapsulated Islet Graft Outcomes in Mice
Background Understanding the effects of capsule composition and transplantation site on graft outcomes of encapsulated islets will aid in the development of more effective strategies for isletExpand
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Physiological 3D tissue model of the airway wall and mucosa
This protocol describes the setup, maintenance and characteristics of a tissue-engineered model of the human bronchial mucosa that can be used for basic physiology and pathophysiology studies. TheExpand
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, CCL 21 Escape by Tumors That Express the Chemokine Induction of Lymphoidlike Stroma and Immune
. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained byExpand
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Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets
To explore the effects immune‐isolating encapsulation has on the insulin secretion of pancreatic islets and to improve our ability to quantitatively describe the glucose‐stimulated insulin releaseExpand
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