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Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase*
The activity of lysophospholipase D for exogenous lysphosphatidylcholine in human serum was found to increase in normal pregnant women at the third trimester of pregnancy and to a higher extent in patients in threatened preterm delivery, suggesting its roles in induction of parturition.
Increased Production of Bioactive Lysophosphatidic Acid by Serum Lysophospholipase D in Human Pregnancy1
It is found that lysophospholipase D activity producing palmitoyl-LPA in human serum gradually increased during pregnancy, and this results suggest that LPA formed by increased activity of lysolymphine D in blood might participate in maintenance of pregnancy.
Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta.
The stimulatory actions of LPA were suggested to be rather specific from the following findings: their stimulation of DNA synthesis increased with an increase in their acyl moiety and lysophosphatidylcholine provoked a slow sustained increase in Ca2+ concentration in an external Ca(2+)-dependent manner.
Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of In vitro fertilization patients.
The results suggest that human follicular fluid has LPLD activity, and this was confirmed by experiments with follicular fluids mixed with an exogenous radioactive LPC, which showed preference for unsaturated over saturated LPCs, similar to plasma L PLD, indicating that it originated from the circulation.
Ether‐linked analogue of 2‐arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species
It is found that 2‐AG ether is not present, at least in an appreciable amount, in the rat brain by gas chromatography‐mass spectrometry analysis and fluorometric high performance liquid chromatography analysis.
Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor.
The potential involvement of a lipid phosphoric acid receptor, which could form a component of the activation pathway associated with various lysophospholipids and analogues, such as PAF, via a phospholipase D activation, is discussed.