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[Research and development of the free radical scavenger edaravone as a neuroprotectant].
Edaravone represents a promising neuroprotectant for drug therapy in acute cerebral ischemia, and a study using proton magnetic resonance spectroscopic techniques showed that edaravone preserved N-acetyl-aspartate in stroke patients, a promising neuronal marker in the brain. Expand
Research and development of the free radical scavenger edaravone as a neuroprotectant
Increasing data suggest that oxygen free radical species play detrimental roles in ischemic diseases. A free radical scavenger capable of inhibiting oxidative injury is expected to become a new drugExpand
Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors.
The results suggest that BP-554 acts as a selective 5-HT1A receptor agonist in vivo. Expand
Design and syntheses of 4-acylaminopyridine derivatives: Novel high affinity choline uptake enhancers II
Abstract 4-Acylaminopyridine derivatives were synthesized and found to have high affinity choline uptake improvement activity. Optimum activity was obtained when the n-propylcarbonyl group wasExpand
[Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in renal hypertensive dogs].
Findings indicate that a certain vasodilating activity may contribute to the antihypertensive mechanism of betaxolol. Expand
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and mongolian gerbils.
Improvement by MCI-2016 of behavioral impairment observed in the animals treated with scopolamine, hypoxia or ischemia may be, at least partly, attributed to the amelioration of decreased ACh level in the brain. Expand
Effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on the scopolamine-induced deficit of spontaneous alternation behavior in rats.
MCI-2016 was shown to improve the scopolamine-SA at doses of 25 to 100 mg/kg p.o.o and it may be suggested that the present model is relatively sensitive to those drugs which affect the cholinergic mechanism either directly or indirectly. Expand
Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on survival time and brain monoamine levels in bilaterally carotid-artery-ligated gerbils.
MCI-2016 is a new drug which has anti anoxic, EEG activating and memory retrieval effects in laboratory evaluations and is reported to be effective for the treatment of cerebrovascular disease in recent clinical trials. Expand
Synthesis of porcine leumorphin and some of its biological activities
The concept that leumorphin is a new type of opioid peptide is supported and that the synthetic preparation will be useful for further biological and immunological studies on this peptide. Expand
Vascular effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, in isolated rat arteries.
The results suggest that betaxolol possesses a direct vasodilating action, and the action may be due to the inhibition of Ca2+ influx across the cell membrane. Expand