A. Tiwari

Publications29
h-index7
Citations138
Highly Influential Citations3
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New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine†
S-Adenosylmethionine decarboxylase (AdoMetDC) is a critical enzyme in the polyamine biosynthetic pathway and depends on a pyruvoyl group for the decarboxylation process. The crystal structures of the… Expand
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Carbonic anhydrase in Tectona grandis: kinetics, stability, isozyme analysis and relationship with photosynthesis.
Carbonic anhydrase (CA, EC: 4.2.1.1) activity in teak (Tectona grandis L.f.) was studied to determine its characteristics, kinetics and isozyme patterns. We also investigated effects of leaf age,… Expand
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Inserting intrauterine devices in nulliparous women : is misoprostol beneficial ? A registered clinical trial
Background: To determine if misoprostol use prior to intrauterine device (IUD) insertion decreases pain and eases insertion in nulliparous women. Study Design: Nulliparous women requesting IUDs for… Expand
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Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents.
Seven new (2-chloroethyl)nitrosocarbamates have been synthesized as potential anticancer alkylating agents. These compounds were designed with carrier moieties that would either act as prodrugs or… Expand
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Conjunctival impression cytology in xerophthalmia among rural children.
The advent of Conjunctival Impression Cytology (CIC) has opened a new chapter in the detection of Vitamin A deficiency as it is a simplified field technique. The need for such a technique was of… Expand
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4-Demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine.
Penclomedine [3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine], an antitumor agent, is currently in Phase I clinical trials and is believed to be a prodrug. In these studies, cerebellar… Expand
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Determination of the phamacophore of penclomedine, a clinically-evaluated antitumor pyridine derivative.
The main objective of this investigation was to identify the reactive pharmacophore in penclomedine (PEN, 3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl) pyridine) for in vivo antitumor activity and… Expand
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Synthesis and antitumor activity of several new analogues of penclomedine and its metabolites.
Analogues of penclomedine (PEN, 3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine) and its metabolites have been synthesized and evaluated as potential antitumor agents. PEN and 4-DMPEN… Expand
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Chemical composition of Inula cuspidata C.B. Clarke
Thymyl isobutyrate, thymol, thymyl isovalerate, 8a-hydroxy presilphiperfolene and intermedeol have been isolated from steam volatile extract of Inula cuspidata and identified from their spectral… Expand
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Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolite of penclomedine
Abstract. Purpose: The purpose of this investigation was to compare the antitumor activities of a series of acyl derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma metabolite of… Expand
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