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Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes
It has been demonstrated that α-synuclein can aggregate and contribute to the pathogenesis of some neurodegenerative diseases and it is capable of hindering autophagy in neuronal cells. Here, weExpand
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Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function
BackgroundDiesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEPExpand
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killerFLIP: a novel lytic peptide specifically inducing cancer cell death
One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cellsExpand
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Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus.
OBJECTIVE Estrogens influence many physiologic processes and are also implicated in the development or progression of numerous diseases, including autoimmune disorders. Aberrations of lymphocyteExpand
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Schwann cell autophagy counteracts the onset and chronification of neuropathic pain
Summary Rapamycin enhances autophagic flux of Schwann cells, reduces prooxidant and proinflammatory proteins, and prevents neuropathic pain; autophagy deficiency induces exacerbated pain and delaysExpand
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Estrogen receptor β ligation inhibits Hodgkin lymphoma growth by inducing autophagy
Although Hodgkin lymphoma (HL) is curable with current therapy, at least 20% of patients relapse or fail to make complete remission. In addition, patients who achieve long-term disease-free survivalExpand
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IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing
Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responsesExpand
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Changes in membrane lipids drive increased endocytosis following Fas ligation
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes. The prototypic deathExpand
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Abstract A091: IL-33 activates antitumoral toxicity in eosinophils through stimulation of contact-dependent degranulation
The alarmin IL-33 plays pleiotropic roles in allergy, autoimmunity and inflammation through binding to its specific receptor ST2 expressed by most hematopoietic cells. Emerging evidences suggest anExpand