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The fatty acid transport function of fatty acid-binding proteins.
TLDR
Data from a number of experimental approaches have provided strong support for defining the FABPs as fatty acid transport proteins, and further studies are necessary to elucidate the fundamental mechanisms by which cellular fatty acid trafficking is modulated by theFABPs. Expand
Tissue-specific Functions in the Fatty Acid-binding Protein Family*
TLDR
Proposed roles for FABPs include assimilation of dietary lipids in the intestine, targeting of liver lipids to catabolic and anabolic pathways, regulation of lipid storage and lipid-mediated gene expression in adipose tissue and macrophages, fatty acid targeting to β-oxidation pathways in muscle, and maintenance of phospholipid membranes in neural tissues. Expand
Effect of sleep deprivation on the human metabolome
TLDR
This report is the first of metabolic profiling during sleep and sleep deprivation and characterization of 24 h rhythms under these conditions, offering a novel view of human sleep/wake regulation. Expand
Characterization of Rhodamine-123 as a Tracer Dye for Use In In vitro Drug Transport Assays
TLDR
The uptake of rhodamine 123 into cells is characterised, and it is demonstrated that this occurs primarily through OATP1A2-mediated facilitated transport at concentrations below 2 µM, and via micelle-mediated passive diffusion above this. Expand
Activated carbon cloth as anode for sulfate removal in a microbial fuel cell.
TLDR
By employing the sulfate-reducing bacterium Desulfovibrio desulfuricans, this approach demonstrates the possibility of electricity generation in a microbialfuel cell (MFC) with concomitant sulfate removal and shows significant potential for harvesting energy from sulfite-rich solutions in the form of electricity. Expand
The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes
TLDR
A novel regulatory loop is described, whereby activation of FXR by statins increases PXR reporter gene expression, potentially enhancing PxR-mediated responses, and has important potential implications for their use within a polypharmacy paradigm. Expand
The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin.
TLDR
The data suggest that, because of structural similarity, lysoPA binds to albumin in a similar manner to long-chain fatty acids. Expand
Dynamic changes in the microbial community composition in microbial fuel cells fed with sucrose
TLDR
The results suggest the presence of functional redundancy within the anodic communities, a probable indication that stable MFC performance can be maintained in changing environmental conditions. Expand
Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line
TLDR
Results suggest that high-dose supplements might not be the most efficient way of increasing the body pool of vitamin C. Expand
Identification of Human Plasma Metabolites Exhibiting Time-of-Day Variation Using an Untargeted Liquid Chromatography–Mass Spectrometry Metabolomic Approach
TLDR
Several of these human plasma metabolites, including specific acylcarnitines and phospholipids, were hitherto not known to be 24-h variant and will be useful in guiding the design and interpretation of future metabolite-based studies. Expand
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