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Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.
Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by reduced rates of FA oxidation and accumulation of lipids. It has been suggested that interventions thatExpand
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Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.
RATIONALE Therapeutically targeting macrophage reverse cholesterol transport is a promising approach to treat atherosclerosis. Macrophage energy metabolism can significantly influence macrophageExpand
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KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury
Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel ofExpand
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  • Open Access
Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans.
The effect of conjugated linoleic acid (CLA), a popular weight-loss supplement, on insulin sensitivity in humans is controversial and has not been extensively studied. To date no studies haveExpand
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Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.
A reduction in fatty acid oxidation has been associated with lipid accumulation and insulin resistance in the skeletal muscle of obese individuals. We examined whether this decrease in fatty acidExpand
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Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms.
Beta-Guanadinopropionic acid (beta-GPA) feeding leads to reductions in skeletal muscle phosphagen concentrations and has been used as a tool with which to study the effects of energy charge onExpand
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Acylcarnitines: potential implications for skeletal muscle insulin resistance
Insulin resistance may be linked to incomplete fatty acid β‐oxidation and the subsequent increase in acylcarnitine species in different tissues including skeletal muscle. It is not known ifExpand
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Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation.
CONTEXT Skeletal muscle lipid content is increased in obesity. Recent evidence suggests that fatty acid (FA) storage as triacylglycerol (TAG) represents a metabolically safe pool compared to the moreExpand
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Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue.
Fatty acid reesterification in adipose tissue is dependent on the generation of glycerol 3-phosphate, and, at least in rodent adipose tissue, this appears to occur primarily throughExpand
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Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
Exposure to high fatty acids (FAs) induces whole body and skeletal muscle insulin resistance. The globular form of the adipokine, adiponectin (gAd), stimulates FA oxidation and improves insulinExpand
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