The effect of flexible low glycemic index dietary advice versus measured carbohydrate exchange diets on glycemic control in children with type 1 diabetes.
- H. Gilbertson, J. Brand-Miller, A. Thorburn, S. Evans, P. Chondros, G. Werther
- MedicineDiabetes Care
- 1 July 2001
Flexible dietary instruction based on the food pyramid with an emphasis of low-GI foods improves HbA(1c) levels without increasing the risk of hypoglycemia and enhances the quality of life in children with diabetes.
Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats.
- A. Thorburn, L. Storlien, A. Jenkins, S. Khouri, E. Kraegen
- Medicine, BiologyAmerican Journal of Clinical Nutrition
- 1 June 1989
Fructose but not glucose feeding led to impaired insulin action in both the liver and peripheral tissues, effects that may depend on antecedent circulating triglyceride levels.
Carbohydrate fermentation decreases hepatic glucose output in healthy subjects.
- A. Thorburn, J. Muir, J. Proietto
- Biology, MedicineMetabolism: Clinical and Experimental
- 1 June 1993
Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y
- D. Ainslie, M. Morris, G. Wittert, H. Turnbull, J. Proietto, A. Thorburn
- BiologyInternational Journal of Obesity
- 1 November 2001
Impaired central leptin sensitivity and overproduction of NPY may contribute to excess fat accumulation caused by estrogen deficiency.
Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake.
- A. Thorburn, B. Gumbiner, F. Bulacan, P. Wallace, R. Henry
- MedicineJournal of Clinical Investigation
- 1 February 1990
To examine whether reduced rates of oxidative (Gox) and non-oxidative (Nox) glucose metabolism in non-insulin-dependent diabetes mellitus (NIDDM) are due to reduced glucose uptake, intrinsic defects…
Current issues in fructose metabolism.
- R. Henry, P. Crapo, A. Thorburn
- MedicineAnnual review of nutrition
- 1991
Overall, there is very little evidence that modest amounts of fructose have detrimental effects on carbohydrate and lipid metabolism in nondiabetic or NIDDM subjects or that its use is particularly advantageous compared to that of other sugars.
Lipid metabolism in non-insulin-dependent diabetes: effects of long-term treatment with fructose-supplemented mixed meals.
- A. Thorburn, P. Crapo, W. Beltz, P. Wallace, J. Witztum, R. Henry
- MedicineAmerican Journal of Clinical Nutrition
- 1 November 1989
Physiologic amounts of fructose are unlikely to have adverse effects on lipid metabolism when consumed by these diabetic subjects in place of sucrose in mixed meals for a prolonged period.
Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin.
- S. Song, S. Andrikopoulos, C. Filippis, A. Thorburn, D. Khan, J. Proietto
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 August 2001
There was a significant positive correlation between alanine gluconeogenesis and fructose-1,6-bisphosphatase protein levels and the site or sites at which metformin acts to inhibit this process, suggesting that excess supply of dietary fat stimulates alAnine gluc oneogenesis via an increase in fructose- 1,6,bisph phosphataseprotein levels.
Long-term effects of dietary fructose on carbohydrate metabolism in non-insulin-dependent diabetes mellitus.
- A. Thorburn, P. Crapo, K. Griver, P. Wallace, R. Henry
- MedicineMetabolism: Clinical and Experimental
- 1990
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment
- M. Heffernan, A. Thorburn, F. Ng
- Biology, MedicineInternational Journal of Obesity
- 2001
HGH and its C-terminal fragment reduce body weight gain, increase fat oxidation, and stimulate lipolysis in obese mice, yet AOD9604 does not interact with the hGH receptor.
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