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Celiac disease: prevalence, diagnosis, pathogenesis and treatment.
TLDR
A greater understanding of the pathogenesis of CD allows alternative future CD treatments to hydrolyse toxic gliadin peptide, prevent toxic gl iadin peptides absorption, blockage of selective deamidation of specific glutamine residues by tissue, restore immune tolerance towards gluten, modulation of immune response to dietarygliadin, and restoration of intestinal architecture.
The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment – Prompt Endoscopy (CADET–PE) study
TLDR
The prevalence of clinically significant upper gastrointestinal findings in adult uninvestigated dyspepsia patients, and their predictability based on history, is unknown.
Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin
TLDR
This data indicates that aspirin use in combination with chemotherapy or a combination of the two is likely to increase the likelihood of ulcer events in patients with high levels of aspirin‐like symptoms.
Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs.
TLDR
Improvements in glucose homeostasis are observed in healthy dogs when they ingest fermentable fibers.
Necrotizing enterocolitis: a multifactorial disease with no cure.
TLDR
Development of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve the understanding of the pathogenesis and lead to discovery of innovative therapeutics.
Oral budesonide for active Crohn's disease. Canadian Inflammatory Bowel Disease Study Group.
TLDR
In an eight-week trial, an oral controlled-release preparation of budesonide at an optimal daily dose of 9 mg was well tolerated and effective against active Crohn's disease of the ileum and proximal colon.
Interrelation of intestinal transport system for manganese and iron.
TLDR
The results suggest that in Fe 2 Mn is absorbed largely by diffusion, whereas in FeD, Mn absorption in the proximal intestine is increased by the enhanced activity of a system which is dose-saturable and can be competitively inhibited by Fe.
Intestinal sugar transport.
TLDR
The early studies that contributed to the development of a working model of intestinal sugar transport are reviewed, and the recent advances made in understanding the process by which sugars are absorbed in the intestine are detailed.
Safety of the long-term use of proton pump inhibitors.
TLDR
The PPIs are a safe class of medications to use long-term in persons in whom there is a clear need for the maintenance of extensive acid inhibition, and the key is to use PPIs only when clearly indicated, and to reassess continued use so that long- term therapy is used judiciously.
Interactions of saturated, n-6 and n-3 polyunsaturated fatty acids to modulate arachidonic acid metabolism.
TLDR
The efficacy of n-3 fatty acids in reducing arachidonic acid level is dependent on the linoleic acid to saturated fatty acid ratio of the diet consumed, and both linseed oil- or fish oil-containing diets inhibited conversion of linoleIC acid to gamma-linolenic acid.
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