Decoding of cytosolic calcium oscillations in the mitochondria
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
Quasi‐synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
It is demonstrated that maximal activation of mitochondrial Ca2+ uptake is evoked by IP3‐induced perimitochondrial [Ca2+] elevations, which appear to reach values >20‐fold higher than the global increases of [Ca 2+]c.
Spatial and temporal aspects of cellular calcium signaling
- A. Thomas, G. Bird, G. Hajnóczky, L. D. Robb-Gaspers, J. Putney
- BiologyThe FASEB Journal
- 1 November 1996
The mechanisms and physi‐ological significance of this behavior in nonexcitable cells are discussed, in which the primary mechanism of Ca2+ mobilization is through (l,4,5)IP3‐dependent Ca 2+ release from intracellular stores.
Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacks.
The ectopic expression of an IP3 binding protein has been used to decrease the rate of IP3 turnover experimentally, resulting in a dose-dependent slowing and eventual quenching of the Ca2+ oscillations, consistent with a model based on positive feedback of Ca2- on IP3 production.
Calcium Signal Transmission between Ryanodine Receptors and Mitochondria*
- G. Szalai, G. Csordás, B. Hantash, A. Thomas, G. Hajnóczky
- BiologyJournal of Biological Chemistry
- 19 May 2000
Activation of the mitochondrial Ca2+ exchangers accounts for rapid reversal of the [Ca2+] m response with little contribution from the permeability transition pore, which allows mitochondria to respond rapidly to single [Ca 2+] c spikes in cardiac cells.
Integrating cytosolic calcium signals into mitochondrial metabolic responses
- L. D. Robb-Gaspers, P. Burnett, G. Rutter, R. Denton, R. Rizzuto, A. Thomas
- BiologyEMBO Journal
- 1 September 1998
Stimulation of hepatocytes with vasopressin evokes increases in cytosolic free Ca2+ ([Ca2+]c) that are relayed into the mitochondria, where the resulting mitochondrial Ca2+ ([Ca2+]m) increase…
Coordination of Ca2+ Signaling by Intercellular Propagation of Ca2+ Waves in the Intact Liver (*)
It is concluded that intercellular Ca2+ waves may provide a mechanism to coordinate responses across the functional units of the liver.
The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate
It is reported that Ins(l,4,5)P3-induced channel activation in permeabilized hepatocytes is followed by a time-dependent inactivation, which is a direct consequence of ligand binding.
Minimal requirements for calcium oscillations driven by the IP3 receptor
Ca2+]c oscillations can be driven by a coupled process of Ca2+‐induced activation and obligatory intrinsic inactivation of the Ca2-sensitized state of the IP3R, without a requirement for occupation of the inhibitory Ca2‐‐binding site.