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Current approaches and challenges for the metabolite profiling of complex natural extracts.
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product research. Obtaining precise information on the chemical composition of complex natural extractsExpand
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Fast gas chromatography and negative-ion chemical ionization tandem mass spectrometry for forensic analysis of cannabinoids in whole blood.
The present work describes a fast gas chromatography/negative-ion chemical ionization tandem mass spectrometric assay (Fast GC/NICI-MS/MS) for analysis of tetrahydrocannabinol (THC),Expand
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Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications
AbstractBecause of the emergence of dried blood spots (DBS) as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories, different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment. Expand
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On-line desorption of dried blood spot: A novel approach for the direct LC/MS analysis of micro-whole blood samples.
The aim of this work is to present a new concept, called on-line desorption of dried blood spots (on-line DBS), allowing the direct analysis of a dried blood spot coupled to liquid chromatographyExpand
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Automated system for on-line desorption of dried blood spots applied to LC/MS/MS pharmacokinetic study of flurbiprofen and its metabolite.
This paper illustrates the development of an automated system for the on-line bioanalysis of dried blood spots (on-line DBS). In this way, a prototype was designed for integration into a conventionalExpand
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Rapid LC-MS/MS quantification of the major benzodiazepines and their metabolites on dried blood spots using a simple and cost-effective sample pretreatment.
BACKGROUND Dried blood spots (DBS) sampling has gained popularity in the bioanalytical community as an alternative to conventional plasma sampling, as it provides numerous benefits in terms of sampleExpand
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Drug vaping applied to cannabis: Is “Cannavaping” a therapeutic alternative to marijuana?
Therapeutic cannabis administration is increasingly used in Western countries due to its positive role in several pathologies. Dronabinol or tetrahydrocannabinol (THC) pills, ethanolic cannabisExpand
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Three‐dimensional imaging MS of lipids in atherosclerotic plaques: Open‐source methods for reconstruction and analysis
Three‐dimensional MALDI imaging MS (IMS) is a growing branch of IMS still requiring developments in methodology and technology to make the technique routinely accessible. Expand
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A systematic review of passive exposure to cannabis.
Passive exposure to cannabis smoke may induce effects on behavior and psychomotor skills, and have legal consequences, including the risk of being falsely considered as a cannabis user. This canExpand
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Quantitative and qualitative profiling of endocannabinoids in human plasma using a triple quadrupole linear ion trap mass spectrometer with liquid chromatography.
Owing to the large implication of endocannabinoids (ECs) in many physiological and pathophysiological processes, a rapid liquid chromatography/electrospray ionisation triple quadrupole linear ionExpand
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