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Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans
TLDR
The findings suggest that in humans, as in other mammals, the MC1R is a control point in the regulation of pigmentation phenotype and, more importantly, that variations in this protein are associated with a poor tanning response. Expand
Control and function of sebaceous glands.
TLDR
This review describes the various types of sebaceous glands, their locations, and where possible their different functions, and describes the role of retinoids and their mode of action in the treatment of acne. Expand
Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families.
TLDR
Genetic analysis of families with generalized vitiligo and this specific constellation of associated autoimmune disorders will be important to identify the mechanisms of genetic susceptibility to autoimmunity. Expand
Pheomelanin as well as eumelanin is present in human epidermis.
TLDR
The present findings could be particularly significant in view of recent suggestions that pheomelanin, rather than protecting the skin against UV radiation, may actually contribute to UV-induced skin damage. Expand
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.
TLDR
Variants of the MC1R gene are likely to be causally associated with the development of melanoma, and the Asp84Glu variant was only present in melanoma cases and appears to be of particular significance. Expand
Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells.
TLDR
It is concluded that melanosomal pH is an essential factor which regulates multiple stages of melanin production and the ratio of eumelanin/phaeomelan in production and maturation rate of melanosomes can be regulated by melanosome pH. Expand
Melanocyte Function and Its Control by Melanocortin Peptides
TLDR
It has been shown that α-MSH regulates NO production from melanocytes, and it is possible that the melanocortins regulate the release of other signalling molecules from melanocyte function, which is one of the important regulators of skin homeostasis. Expand
Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor.
TLDR
It would appear that ACTH peptides can serve as natural ligands of the MC-1 receptor on human melanocytes and their presence in the skin suggests that, together with alpha-MSH, they may have a role in the regulation of human melanocyte regulation. Expand
Proopiomelanocortin (POMC), the ACTH/ melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis
TLDR
The release of POMC from skin cells and its functional activity at the MC‐1R highlight the importance of PomC processing as a key regulatory event in the skin. Expand
Does alpha-MSH have a role in regulating skin pigmentation in humans?
TLDR
There is now evidence from several groups that alpha-MSH is capable of stimulating melanogenesis in cultured human melanocytes and rather than producing an overall increase in melanin production, it appears that the peptide acts specifically to increase the synthesis of eumelanin. Expand
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