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Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energyExpand
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Brain Iron Metabolism and CNS Diseases.
Iron is the most abundant trace element in the human body. It is well known that iron is an important component of hemoglobin involved in the transport of oxygen. As a component of various enzymes,Expand
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Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice
ABSTRACT Many pathological conditions linked to cigarette smoking are caused by the production of reactive oxygen species (ROS). The present study was conducted to analyze the effect of ROS on theExpand
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Modulatory effects of taurine on metabolic and oxidative stress parameters in a mice model of muscle overuse.
OBJECTIVE The aim of this study was to investigate the regulatory effects of taurine on the biochemical parameters of muscle injury by overuse. METHODS Male Swiss mice were divided into fourExpand
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Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice
Reactive oxygen species (ROS) are important in the pathogenesis of pulmonary injury induced by cigarette smoke (CS) exposure, and physical exercise (Ex) is useful in combating impaired oxidativeExpand
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Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism.
The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are causedExpand
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β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine–induced hepatic fibrosis in male rats
Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention atExpand
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Methotrexate treatment provokes apoptosis of proliferating keratinocyte in psoriasis patients
Abstract Psoriasis is a chronic inflammatory skin disease characterized by hyper proliferation of keratinocytes. Recent data show that the epidermis thickening in psoriasis may be related toExpand
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Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles
A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediatedExpand
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The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men
Regular exercise can decrease the deleterious effects of aging and limit the development and progression of chronic disease in elderly people, depending on the type, intensity, frequency, andExpand
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