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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
It is demonstrated, across multiple species and tumor models, that obesity results in increased immune aging, tumor progression and PD-1-mediated T cell dysfunction which is driven, at least in part, by leptin. Expand
Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In Vivo
This work has demonstrated physiological disease correction by AAV9 gene transfer in a mouse model of Pompe disease via ECG tracings and that intravenous delivery of the same vector preferentially transduces cardiac tissue in nonhuman primates. Expand
HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.
- J. Marecki, C. Cool, +9 authors S. Flores
- American journal of respiratory and critical care…
- 15 August 2006
The discovery of complex vascular lesions in SHIV-nef- but not SIV-infected animals, and the presence of Nef in the vascular cells of patients with HRPH, suggest that Nef plays a key role in the development of severe pulmonary arterial disease. Expand
Nonhuman primate models of intrauterine cytomegalovirus infection.
This review addresses salient findings with the rhesus macaque model as they relate to HCMV infection and potential avenues of discovery, including studies of intrauterine CMV infection. Expand
Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA.
- C. Leutenegger, J. Higgins, +4 authors T. North
- Biology, Medicine
- AIDS research and human retroviruses
- 10 February 2001
The high sensitivity, increased specificity, wide dynamic range, simplicity, and reproducibility of the real-time SIV RNA quantitation allow the screening of large numbers of samples and make this method especially suitable for measuring both viral DNA and RNA levels during vaccine and therapy studies. Expand
Tissue Specificity of Decellularized Rhesus Monkey Kidney and Lung Scaffolds
The results suggest that decellularized scaffolds have an intrinsic spatial ability to influence hESC differentiation by physically shaping cells into tissue-appropriate structures and phenotypes, and that additional approaches may be needed to ensure consistent recellularization throughout the matrix. Expand
Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering.
- K. Nakayama, C. A. Batchelder, Chang I. Lee, A. Tarantal
- Chemistry, Medicine
- Tissue engineering. Part A
- 24 March 2010
It is demonstrated that decellularized kidney sections retain critical structural and functional properties necessary for use as a three-dimensional scaffold and promote cellular repopulation. Expand
Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta).
In utero sonographic findings in fetuses correlated with the gross findings at term, and studies have shown that external genital abnormalities can be produced in male monkey fetuses when exposed to a high oral dose of finasteride, whereas no abnormalities were observed in Fetuses exposed to the i.v. formulation of Finasteride during pregnancy. Expand
Frequency of prenatal loss in a macaque breeding colony
- T. A. Hendrie, P. Peterson, +4 authors A. Hendrickx
- Biology, Medicine
- American journal of primatology
An accurate knowledge of the historical incidence of prenatal loss is essential for management of breeding colonies and for performing developmental toxicity studies in nonhuman primates. Data from… Expand
Identification of bovine Neospora parasites by PCR amplification and specific small-subunit rRNA sequence probe hybridization.
Results indicate that this PCR and probe hybridization system could be a valuable adjunct to serology and immunohistochemistry for the diagnosis of Neospora infections in bovine or primate fetuses. Expand