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JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer
TLDR
It is demonstrated that Ruxolitinib is effective in the inhibition of systemic inflammation in the tumor microenvironment and therefore upregulates CTL infiltration and activation to overcome pancreatic cancer resistance to anti-PD-1 immunotherapy. Expand
Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets
TLDR
This study demonstrates that the HA family can be exploited for developing a biomarker-driven, targeted treatment for bladder cancer, and 4MU, a non-toxic oral HA synthesis inhibitor, is one such candidate. Expand
Molecular Characterization of Renal Cell Carcinoma: A Potential Three-MicroRNA Prognostic Signature
TLDR
The interconnected discovery–validation approach identified a three-miRNA signature as a potential predictor of disease outcome in RCC patients as well as potentially at an early stage detect and predict metastasis. Expand
Colorectal Cancer Screening and Prevention.
TLDR
There is good evidence that calcium supplementation, moderate dairy consumption, reduced red meat consumption, increased physical activity, decreased body mass index, and statin use decrease the risk of colorectal cancer and adenomatous polyps. Expand
A case report of a patient with gallbladder agenesis resulting in a common bile duct injury
TLDR
Gallbladder agenesis can present with symptoms of biliary colic or cholecystitis, and the procedure should be aborted, and further diagnostic testing should be done. Expand
Racial disparities in the use of laparoscopic surgery to treat colonic diverticulitis Are not fully explained by socioeconomics or disease complexity.
TLDR
This study analyzed the relationship between race, socioeconomic status and the use of laparoscopy to address diverticulitis to demonstrate disparities in surgical treatment. Expand
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia.
TLDR
Biliary dyskinesia includes motility disorders resulting in biliary colic in the absence of gallstones in individuals with acute cholecystitis and choledocholithiasis. Expand
Demographic and clinical factors associated with suicide in gastric cancer in the United States.
TLDR
Female gender, White race, age ≤39 years, and age 70-79 years are factors associated with increased risk of suicide in patients with gastric cancer, and these results will be used to formulate a comprehensive suicide risk factor scoring system for screening all cancer patients. Expand
A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.
TLDR
Results of 451 specimens from both cohorts reveal that the CXCR-4/7+CXCL-12 signature potentially predicts outcome in CRC patients and may allow earlier intervention. Expand
Clinical and epidemiological factors associated with suicide in colorectal cancer
TLDR
Identification of risk factors associated with suicide among patients with CRC is an important step in developing screening strategies and management of psychosocial stressors and could be helpful in formulating a comprehensive suicide risk scoring system for screening all cancer patients. Expand
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