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  • Lucas N. Alberca, María L. Sbaraglini, +6 authors Alan Talevi
  • Medicine, Biology, Computer Science
  • Journal of Computer-Aided Molecular Design
  • 2016 (First Publication: 18 February 2016)
  • Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary importance, there are currently only twoExpand
  • S Scioli Montoto, María L. Sbaraglini, +8 authors Germán A. Islan
  • Medicine, Chemistry
  • Colloids and surfaces. B, Biointerfaces
  • 2018 (First Publication: 31 March 2018)
  • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) represent promising alternatives for drug delivery to the central nervous system. In the present work, four differentExpand
  • Rosemary C. Dietrich, Lucas N. Alberca, +4 authors Luciana Gavernet
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2018 (First Publication: 10 April 2018)
  • Nowadays, the pharmacological therapy for the treatment of Chagas disease is based on two old drugs, benznidazole and nifurtimox, which have restricted efficacy against the chronic phase of theExpand
  • Alan Talevi
  • Medicine, Computer Science
  • Methods in molecular biology
  • 2018
  • The term drug design describes the search of novel compounds with biological activity, on a systematic basis. In its most common form, it involves modification of a known active scaffold or linkingExpand