• Publications
  • Influence
Manganese action in brain function
  • A. Takeda
  • Biology, Medicine
  • Brain Research Reviews
  • 2003
Manganese, an essential trace metal, is supplied to the brain via both the blood-brain and the blood-cerebrospinal fluid barriers. There are some mechanisms in this process and transferrin may beExpand
  • 460
  • 19
Movement of zinc and its functional significance in the brain
  • A. Takeda
  • Biology, Medicine
  • Brain Research Reviews
  • 1 December 2000
Zinc, an essential nutrient, is supplied to the brain via both the blood-brain and blood-cerebrospinal fluid barriers. Zinc is most concentrated in the limbic system, i.e. the hippocampus andExpand
  • 371
  • 11
Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy
8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levelsExpand
  • 248
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  • PDF
Anxiety-like behavior of young rats after 2-week zinc deprivation
The relationship between neuronal function in the brain and neuropsychological behavior were analyzed in young rats fed a zinc-deficient diet for 1-2 weeks. Serum zinc concentration was less than 50%Expand
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Adult neurogenesis with 5-HT expression in lesioned goldfish spinal cord
In contrast to mammals, spontaneous nerve regeneration occurs in the teleost spinal cord. In the present study, we examined whether neurogenesis is involved in posttraumatic regeneration in theExpand
  • 37
  • 7
Zinc homeostasis and functions of zinc in the brain
  • A. Takeda
  • Medicine, Chemistry
  • Biometals
  • 1 September 2001
The brain barrier system, i.e., the blood-brain and blood-cerebrospinal fluid barriers, is important for zinc homeostasis in the brain. Zinc is supplied to the brain via both barriers. A largeExpand
  • 293
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  • PDF
Insight into zinc signaling from dietary zinc deficiency
Zinc is necessary for not only brain development but also brain function. Zinc homeostasis in the brain is tightly regulated by the brain barrier system and is not easily disrupted by dietary zincExpand
  • 156
  • 6
Manganese Transport in the Neural Circuit of Rat CNS
To study manganese (Mn) transport in the neural circuit of rat CNS, brain isotope distribution after 54Mn injection into the brain was analyzed by autoradiography. One day after 54MnCl2 injectionExpand
  • 101
  • 6
Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease
The changes of regional cerebral blood flow (rCBF) in Parkinson's disease (PD) were investigated. Because of individual differences in brain volume and the extent of brain atrophy, previousExpand
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Decreased Brain Zinc Availability Reduces Hippocampal Neurogenesis in Mice and Rats
  • S. W. Suh, S. Won, +6 authors J. Liu
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 September 2009
In the adult brain, neurogenesis occurs in the subgranular zone of the dentate gyrus (DG), where high levels of vesicular zinc are localized in the presynaptic terminals. To determine whether zincExpand
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