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Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome.
- S. Ahmed, A. Cheng, I. Hughes
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 February 2000
The phenotypic heterogeneity among clinically diagnosed cases of AIS emphasizes the need for appropriate comprehensive evaluation of male under-masculinization and there is some correlation between the phenotypesic features and the abnormalities discovered on mutational analysis of the AR gene, but there is a need to improve this further by developing optimal bioassays of AR function.
Changes in cortisol metabolism following rifampicin therapy.
CORTICOSTERONE‐SECRETING TUMOURS: WITH AND WITHOUT RENAL ARTERY STENOSIS
- I. Mills, R. Cook, J. Galley, O. M. Edwards, A. Tait
- Medicine, BiologyClinical endocrinology
- 1 October 1980
Two cases of corticosterone‐secreting adrenal adenomata are reported. Both patients were middle‐aged females in whom the clinical course spanned several years before the diagnosis was made. Severe…
Modulation of 3β‐hydroxysteroid dehydrogenase (3β‐HSD) activity in the equine placenta by pregnenolone and progesterone metabolites
It is demonstrated that a marked inhibition of 315-HSD activity is caused by 5-pregnenes and 5α- pregnanes in the range of blood plasma concentrations in the pregnant mare.
Modulation of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity in the equine placenta by pregnenolone and progesterone metabolites.
3beta-HSD activity in the equine placenta was measured using a tritium release assay with [3alpha-3H] pregnenolone as substrate and 3beta-hydroxy compounds showed noncompetitive or mixed inhibition.
The conversion of 23,24-dinor-chol-5-en-3 -ol into steroid hormones.
- A. Tait
- ChemistryThe Biochemical journal
- 1 June 1972
It is widely accepted that cholesterol is the precursor of the steroid hormones. However, there are reports suggesting that there could be some other pathway not involving cholesterol (Heard et al.,…
The conversion of 23,24-dinor-5-cholen-3beta-ol to cortisol by the canine adrenal.
- A. Tait
- 1 November 1973
The biosynthesis of 23,24-dinor-5-cholene-3β,20-diol and 23,24-dinor-5-cholene-3β, 21-diol
- A. Tait
- 1 August 1973
Steroid hormone biosynthesis by a sesterterpene pathway in the rat and rabbit testis.
Steroid biosynthesis by a sesterterpene pathway in the rat adrenal gland in vitro.