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Correlation between Resistance of Pseudomonas aeruginosa to Quaternary Ammonium Compounds and Expression of Outer Membrane Protein OprR
Results suggested that OprR significantly participated in the adaptation of P. aeruginosa to QACs, such as P-12 and BAC, which is commonly used as a disinfectant. Expand
Investigation of the chaperone function of the small heat shock protein — AgsA
The data demonstrate that AgsA has several regions necessary for efficient chaperone activity: region(s) important for lysozyme chaper one activity are located outer surface of the oligomeric complex while those region(S)Important for insulin are located inside the oligomersic complex and those for MDH are located within the N-terminal arm. Expand
Characterization of recombinant Streptococcus mitis‐derived human platelet aggregation factor
Characterization of recombinant Streptococcus mitis‐derived human platelet aggregation factor and its role in cell reprograming is described. Expand
Effects of Pine Bark Extract on Lipid Metabolism in Rats
血中総コレステロール (TC) およびLDLコレステロール (LDL-C) が上昇すると動脈硬化などの疾病リスクが高まるが, ポリフェノールの摂取によって脂質代謝が改善し, 疾病リスクが低下することが知られている。松樹皮抽出物はポリフェノールを豊富に含むのが特徴であり, 血中や肝臓中のTCおよびLDL-Cを低下させる効果が期待されている。そこで,Expand
Role of Streptococcus intermedius DnaK chaperone system in stress tolerance and pathogenicity
A dnaK knockout mutant is constructed that exhibited slow growth, thermosensitivity, accumulation of GroEL in the cell, and reduced cytotoxicity to HepG2 cells and showed that the S. intermedius DnaK chaperone system has important functions in quality control of cellular proteins but has less participation in the modulation of expression of pathogenic factors. Expand
Role of Catabolite Control Protein A in the Regulation of Intermedilysin Production by Streptococcus intermedius
Data show that S. intermedius can modulate ily expression and growth rate through catabolite control protein A-mediated monitoring of the extracellular glucose/utilizable carbohydrate concentration. Expand
Anti-Annexin A2 IgM Antibody in Preterm Infants: Its Association with Chorioamnionitis
The fetal autoimmunoreactivity against the fetomaternal interface in preterm infants is indicated: anti-annexin A2 IgM antibody inhibited plasmin generation and expressed at fetal chorion and amnion membranes. Expand
Evaluation of the effectiveness of the potent bis‐quaternary ammonium compound, 4,4′‐(α,ω‐hexametylenedithio) bis (1‐octylpyridinium bromide) (4DTBP‐6,8) on Pseudomonas aeruginosa
This study aimed to assess the effectiveness of 4DTBP‐6,8 against Pseudomonas aeruginosa, a prevalent hospital pathogen. Expand
Positive- and Negative-Control Pathways by Blood Components for Intermedilysin Production in Streptococcus intermedius
Blood contains factors that stimulate and inhibit ILY expression and activity, which may affect pathogenicity of S. intermedius, and human plasma contains immunoglobulins that can neutralize ILY, MsgA, and NanA activities. Expand
Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells
Analysis of the expression pattern of bone-related genes suggests that PACE4 participates in bone formation at least in osteoblast differentiation, and estrogen receptor-mediated stimuli induce osteoblow differentiation through the upregulation of PACE 4 expression. Expand