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The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases
TLDR
Recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases is presented. Expand
Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota
TLDR
Overall, the findings suggest that, in the absence of any contact with microbiota, skin wound healing is accelerated and scarless, partially because of reduced accumulation of neutrophils, increased accumulation of alternatively activated healing macrophages, and better angiogenesis at wound sites. Expand
The Essential Role of the Intestinal Microbiota in Facilitating Acute Inflammatory Responses1
TLDR
The lack of intestinal microbiota is accompanied by a state of active IL-10-mediated inflammatory hyporesponsiveness, consistent with the prevention of reperfusion-associated injury by the exogenous administration of IL- 10 to conventional mice. Expand
A Role for Gut Microbiota and the Metabolite‐Sensing Receptor GPR43 in a Murine Model of Gout
TLDR
This study was undertaken to investigate the relevance of gut microbiota, acetate, and the metabolite‐sensing receptor GPR43 in regulating inflammation in a murine model of gout. Expand
The Role of Probiotics and Prebiotics in Inducing Gut Immunity
TLDR
The concept of prebiotics, probiotics, and symbiotics are described and the most recently well-established scientific findings regarding the direct and indirect mechanisms by which these dietary approaches can influence gut immunity are covered. Expand
The Required Role of Endogenously Produced Lipoxin A4 and Annexin-1 for the Production of IL-10 and Inflammatory Hyporesponsiveness in Mice1
TLDR
The data demonstrate that inflammatory responsiveness is tightly controlled by the presence of the microbiota and that the innate capacity of germfree mice to produce IL-10 is secondary to their endogenous greater ability to produce lipoxin A4 and annexin-1. Expand
Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice.
TLDR
It is suggested that PTX3 is an essential part of the ability of a host to deal with bacterial infection and depending on the intensity of the inflammatory response induced by a given inoculum, the expression ofPTX3 may favor or disfavor the influx of neutrophils and the abilityof the murine host toDeal with pulmonary infection with K. pneumoniae. Expand
Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury.
TLDR
A role for K(ATP) channels in mediating neutrophil influx and consequent reperfusion-associated injury in rats is suggested, and the lack of effect of these drugs on the reperfusions-associated hypotension and lethality may limit their usefulness after severe reperFusion injury. Expand
Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis
TLDR
Activation of Mas receptors decreases neutrophil influx and cytokine production and causes significant amelioration of arthritis in experimental models ofthritis in rats and mice. Expand
Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury
TLDR
CINC‐1 and possibly other CXC chemokines, acting on CXCR2, have an important role during I/R injury and drugs, such as Repertaxin, developed to block the function of the CX CR2 receptor may be effective at preventing reperfusion injury in relevant clinical situations. Expand
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