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New sucrose phenylpropanoid esters from Polygonum perfoliatum.
The structures of these phenylpropanoid glycosides were determined on the basis of their NMR and mass spectroscopic data and are new members of this class.
Neoflavonoids from Polygonum perfoliatum.
Four neoflavonoids, 3,4-dihydro-5-hydroxy-7-methoxy-4-(4'-methoxyphenyl)coumarin, were isolated from the whole plant of Polygonum perfoliatum.
Bisnortriterpenes from Salacia madagascariensis.
Three new bisnortriterpene quinone methide, 20-epi-isoiguesterinol, and a new 6-oxophenolic triterpene,6-oxoisoiguestersterin, as well as two known compounds were isolated from the petroleum ether extract of the roots of Salacia madagascariensis.
Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids.
It is apparent that presence of the C-3 ester is necessary for significant activity, and variations in the ester group are not accompanied by marked changes in activity, so a free carbinolamide at C-9 is advantageous for optimal activity.
Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.
Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.
Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum.
Two new protein kinase C inhibitory glycosides were isolated from Polygonum pensylvanicum by chromatographic techniques guided by bioassays for PKC inhibition and established primarily by analysis of 1H- and homonuclear correlated nmr and high-resolution fab mass spectra of 1 and 2 and the derived octaacetate, 3.
New cucurbitacins from Phormium tenax and Marah oreganus
The acid sensitivity of the 2β-hydroxy-3-keto system found in cucurbitacin D was demonstrated and a new cucurbitsacin was isolated from Marah oreganus.
Dihydroagarofuran sesquiterpene alkaloids from Maytenus putterlickoides.
Two new dihydroagarofuran sesquiterpene alkaloids, putterines A (2) and B (3), and a known alkaloid, mayteine (1), were isolated from the root of Maytenus putterlickoides. The structures of these
Vanicosides C-F, new phenylpropanoid glycosides from Polygonum pensylvanicum.
A new, more efficient isolation procedure has been developed to facilitate separation of homologues of vanicosides A and B from the complex extract of Polygonum pensylvanicum.