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Vanilloid (Capsaicin) receptors and mechanisms.
TLDR
This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine. Expand
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
TLDR
It is argued that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes, and emerging data indicate that TRPs could be useful in treating disorders other than pain, such as urinary urge incontinence, chronic cough and irritable bowel syndrome. Expand
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.
TLDR
The finding that VR1 is expressed not only in primary sensory neurons but also in several brain nuclei is of great importance in that it places VRs in a much broader perspective than pain perception. Expand
TRP channels and pain.
TLDR
Current evidence that supports particular TRP channels as targets for novel analgesic drugs, along with potential adverse effects that may limit drug development are evaluated. Expand
Transient receptor potential channels as therapeutic targets
TLDR
This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention. Expand
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment
TLDR
The present results suggest a discrete expression of vanilloid receptors in the brain stem (sensory nuclei); although intrinsic vanilloids receptor-expressing neurons are though to exist in the rat brain, they remain undetected by the present [3H]RTX autoradiography methodology. Expand
Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
TLDR
An overview of the functional properties of mammalian TRP channels is given, their roles in acquired and hereditary diseases are described, and their potential as drug targets for therapeutic intervention is discussed. Expand
Biochemical pharmacology of the vanilloid receptor TRPV1
TLDR
Findings imply an important role for aberrant TRPV1 expression in the development of neuropathic pain and hyperalgesia and a better understanding of these pathways has obvious implications for rational drug development. Expand
Transient receptor potential (TRP) channels: a clinical perspective
TLDR
There has been a recent upsurge in the amount of work that expands TRP channel drug discovery efforts into new disease areas such as asthma, cancer, anxiety, cardiac hypertrophy, as well as obesity and metabolic disorders. Expand
Capsaicin (TRPV1 Agonist) Therapy for Pain Relief: Farewell or Revival?
TLDR
It is argued that TRPV1 agonists and antagonists are not mutually exclusive but rather complimentary pharmacologic approaches for pain relief and it is predicted a “revival” for capsaicin and other TRPVs 1 agonists in the clinical management of pain associated with inflammation, metabolic imbalances, infections, and cancer, despite the current focus of the pharmaceutical industry on TRpV1 antagonists. Expand
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