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Association analysis identifies 65 new breast cancer risk loci
TLDR
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
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Large-scale genotyping identifies 41 new loci associated with breast cancer risk
TLDR
A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
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Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment.
TLDR
Age at treatment has a major effect on risk of second malignancy after Hodgkin's disease and RRs of several important malignancies are much greater for patients who are treated when young, although absolute excess risks are greater for older patients.
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Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial.
TLDR
The results show that allogeneic CTLs are a safe and rapid therapy for PTLD, bypassing the need to grow C TLs for individual patients, and the response rate in this poor prognosis patient group is encouraging.
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Genome-wide association study identifies five susceptibility loci for glioma
TLDR
Meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs shows that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
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Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study.
TLDR
The risk of death from myocardial infarction after treatment for Hodgkin disease remains high for at least 25 years, and is related to supradiaphragmatic radiotherapy but may also be related to anthracycline and vincristine treatment.
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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
TLDR
15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.
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Genome-wide association studies identify four ER negative–specific breast cancer risk loci
TLDR
SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.
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Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
TLDR
The risk of mortality from ischaemic heart disease is exceptionally high in young adult women with Type 1 diabetes, with rates similar to those in men with Type 2 diabetes under the age of 40, and the need to identify and treat coronary risk factors in these young patients is emphasised.
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Epidemiology of Health Effects of Radiofrequency Exposure
We have undertaken a comprehensive review of epidemiologic studies about the effects of radiofrequency fields (RFs) on human health in order to summarize the current state of knowledge, explain the…
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