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Musashi1: An Evolutionally Conserved Marker for CNS Progenitor Cells Including Neural Stem Cells
In situ detection of neural progenitor cells including stem-like cells is essential for studying the basic mechanisms of the generation of cellular diversity in the CNS, upon which therapeuticExpand
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Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also found in many sporadic cancers and a few related autosomal dominant hamartoma syndromes. PTEN is aExpand
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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
  • A. Suzuki, R. Thies, +4 authors N. Ueno
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 October 1994
Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. ToExpand
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T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Pten(flox/-) mice). All Pten(flox/-) mice developExpand
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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an epithelial layer instantaneously generates endogenous electric fields,Expand
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Mammalian phosphoinositide kinases and phosphatases.
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and internal membranes and play pivotal roles in the regulation of a wide variety of cellular processes.Expand
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Coupling grain boundary motion to shear deformation
Abstract Molecular dynamics (MD) simulations confirm that normal grain boundary (GB) motion must often be coupled to tangential translation of grains and will then produce shear deformation of theExpand
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The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis.
Vertebrate embryonic blood formation is regulated by factors that participate in dorsal-ventral patterning and mesoderm induction. The GATA-binding transcription factors are required for normalExpand
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Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice (k5Pten(flox/flox) mice).Expand
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Mesoderm induction by BMP-4 and -7 heterodimers.
Bone morphogenetic proteins (BMPs) are peptide growth factors belonging to the TGF-beta superfamily. A large number of these ligands, including BMP-2, -4 and -7 is expressed during earlyExpand
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