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Echinacea alkylamides modulate TNF‐α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways
Echinacea plant preparations are widely used in the prevention and treatment of common cold. However, so far no molecular mechanism of action has been proposed. We analyzed the standardized tincture… Expand
Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system.
- K. Woelkart, E. Marth, +5 authors R. Bauer
- International journal of clinical pharmacology…
- 1 September 2006
Echinacea is a widely used herbal remedy for the prevention and treatment of the common cold. Recently, many new insights concerning the molecular mode of action of the main lipophilic constituents,… Expand
Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content.
- M. Modarai, J. Gertsch, A. Suter, M. Heinrich, A. Kortenkamp
- Medicine, Chemistry
- The Journal of pharmacy and pharmacology
- 1 April 2007
Echinacea preparations are one of the best selling herbal medicinal products with a well established therapeutic use in the prophylaxis of upper respiratory tract infections. Their consumption is… Expand
Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study
The use of topical preparations for symptom relief is common in osteoarthritis. The effects of ibuprofen (5%) and arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with… Expand
Prevention of influenza virus induced bacterial superinfection by standardized Echinacea purpurea, via regulation of surface receptor expression in human bronchial epithelial cells.
Viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. Such complicated respiratory infections… Expand
Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.
- K. Woelkart, E. Feizlmayr, +4 authors R. Bauer
- Chemistry, Medicine
- Phytotherapy research : PTR
- 1 March 2010
A sensitive LC-ESI-MS method with a solid-phase extraction was established for the determination of bilobalide, ginkgolide A and ginkgolide B in human plasma; bioavailability and pharmacokinetics of… Expand
Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4).
- M. Modarai, Min Yang, A. Suter, A. Kortenkamp, M. Heinrich
- Medicine, Biology
- Planta medica
- 1 March 2010
ECHINACEA is a popular and widely used herbal medicinal product and consequently, studies of its interactions with conventional drugs are of particular importance. We have shown that ECHINACEA… Expand
Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms.
Repetitive administrations of valerian/hops combinations have been widely used for self-administered therapy of sleep disturbances. This investigation focuses on the question if a single… Expand
Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression
- M. Modarai, E. Silva, A. Suter, M. Heinrich, A. Kortenkamp
- Evidence-based complementary and alternative…
- 15 September 2010
A major safety concern with the use of herbal medicinal products (HMP) is their interactions with conventional medicines, which are often mediated via the cytochrome P450 (CYP) system. Echinacea is a… Expand
Pharmacokinetics of the main alkamides after administration of three different Echinacea purpurea preparations in humans.
Establishing the pharmacological basis for efficacy of herbal medicinal products (HMPs) is a continuous challenge. In this context, also the question of bioavailability, the elucidation of metabolic… Expand