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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
TLDR
It is demonstrated that the enoyl-ACP reductase purified from P. falciparum is triclosan sensitive and the existence of the de novo fatty acid biosynthetic pathway in this parasite is established, and a key enzyme of this pathway for the development of new antimalarials is identified. Expand
Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response
TLDR
The experimental results suggest that LBP interacts with LPS and CD14 to form a stable trimolecular complex that has significant functional implications as it allows monocytes to detect the presence of LPS at a concentration as low as 10 pg/ml or 2 pM, and to respond by secreting interleukin‐6. Expand
Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex.
TLDR
The structure of peanut lectin demonstrates that the variability in quaternary association in legume lectins, despite all of them having nearly the same tertiary structure, is not necessarily caused by covalently bound carbohydrate. Expand
A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a β-prism fold
TLDR
The crystal structure of jacalin with methyl-α-D-galactose reveals that each subunit has a three-fold symmetric β-prism fold made up of three four-stranded β-sheets, providing an explanation for the relative affinities of the lectin for galactose derivatives and providing insights into the structural basis of its T-antigen specificity. Expand
Titration calorimetric studies to elucidate the specificity of the interactions of polymyxin B with lipopolysaccharides and lipid A.
TLDR
The negative heat capacity changes provide strong evidence for the role of hydrophobic interactions as the driving force for the association of PmB with LPS and lipid A. Expand
Inhibitors of Nonhousekeeping Functions of the Apicoplast Defy Delayed Death in Plasmodium falciparum
TLDR
It is demonstrated that antibiotics like clindamycin, chloramphenicol, and tetracycline, inhibitors of prokaryotic protein synthesis, invoke the delayed death phenotype in Plasmodium falciparum, too, as evident from a specific reduction of apicoplast genome copy number. Expand
Analyses of carbohydrate recognition by legume lectins: size of the combining site loops and their primary specificity.
TLDR
An extensive analysis of sequences and structures of several legume lectins shows that despite the hypervariability of their combining regions they exhibit within a significant pattern of uniformity, providing a framework for understanding the molecular basis of carbohydrate recognition by legumes lectins and a rationale for redesign of their ligand binding propensities. Expand
Identification, Characterization, and Inhibition of Plasmodium falciparum β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)*
TLDR
The discovery of the inhibitors of FabZ, reported for the first time against any member of this family of enzymes, essential to the type II FAS pathway opens up new avenues for treating a number of infectious diseases including malaria. Expand
gamma-secretase activating protein is a therapeutic target for alzheimer ’s disease: a path-breaking discovery finally paving way towards therapeutic intervention
TLDR
Inhibition of AβP production, by blocking gamma-secretase activity, is at present one of the most promising therapeutic strategies anticipated to slow the progression of Alzheimer’s disease pathology. Expand
Structural basis of the carbohydrate specificities of jacalin: an X-ray and modeling study.
TLDR
The interactions observed in the crystal structures and modeling based on them provide a satisfactory qualitative explanation of the available thermodynamic data on jacalin-carbohydrate interactions and lead to fresh insights into the nature of the binding of glycoproteins by jACalin. Expand
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