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Catalytic Reductive Amination of Aldehydes and Ketones With Nitro Compounds: New Light on an Old Reaction
  • A. Sukhorukov
  • Chemistry, Medicine
  • Frontiers in Chemistry
  • 15 April 2020
Reductive amination of carbonyl compounds with primary amines is a well-established synthetic methodology for the selective production of unsymmetrically substituted secondary and tertiary amines.Expand
Organic and hybrid systems: from science to practice
Organic systems still dominate several traditional areas of chemical science and well-known applications, such as the synthesis of pharmaceutical compounds and drugs. However, a fascinating trend hasExpand
Novel approaches to pharmacology-oriented and energy rich organic nitrogen–oxygen systems
Organic compounds bearing semi-polar nitrogen–oxygen bonds are considered as perspective platform for designing socially important medications and high energy materials. Herein, recently developedExpand
Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.
In the present study, we used solution combustion synthesis-bismuth oxide (Bi2O3) as catalyst for the simple and efficient synthesis of 1,2-oxazine based derivatives ofExpand
Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases. In theExpand
Synthesis of PDE IVb inhibitors. 1. Asymmetric synthesis and stereochemical assignment of (+)- and (-)-7-[3-(cyclopentyloxy)-4-methoxyphenyl]hexahydro-3H-pyrrolizin-3-one.
Asymmetric synthesis of GlaxoSmithKline's highly potent phosphodiesterase inhibitor 1 has been accomplished in nine steps and 16% overall yield. The original strategy suggested involves as a key stepExpand
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.
Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). The test revealed that the newly synthesized compounds had potent inhibitionExpand