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GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.
Eukaryotic chromosomal DNA replication requires a two-step assembly of replication proteins on origins; formation of the prereplicative complex (pre-RC) in late M and G1 phases of the cell cycle, andExpand
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The phosphorylated C‐terminal domain of Xenopus Cut5 directly mediates ATR‐dependent activation of Chk1
ATR‐dependent activation of the kinase Chk1 is the initial step in signal transduction in the DNA replication checkpoint, which allows a cell to enter mitosis only after the completion of DNAExpand
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The 3′ → 5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae
DNA polymerases II (ε) and III(δ) are the only nuclear DNA polymerases known to possess an intrinsic 3′ → 5′ exonuclease in Saccharomyces cerevisiae. We have investigated the spontaneous mutatorExpand
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A third essential DNA polymerase in S. cerevisiae
DNA polymerases I and III are essential for viability of S. cerevisiae. We have cloned and analyzed POL2, the gene encoding the catalytic subunit of the third nuclear DNA polymerase, DNA polymeraseExpand
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Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts
DNA polymerases δ and ɛ (Polδ and Polɛ) are widely thought to be the major DNA polymerases that function in elongation during DNA replication in eukaryotic cells. However, the precise roles of theseExpand
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Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability
Background: MCM10 is essential for the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Mcm10p functionally interacts with components of the pre‐replicative complex (Mcm2‐Mcm7Expand
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The DNA polymerase activity of Pol ε holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts
BackgroundDNA polymerase ε (Pol ε) is involved in DNA replication, repair, and cell-cycle checkpoint control in eukaryotic cells. Although the roles of replicative Pol α and Pol δ in chromosomal DNAExpand
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The DNA Polymerase Domain of polε Is Required for Rapid, Efficient, and Highly Accurate Chromosomal DNA Replication, Telomere Length Maintenance, and Normal Cell Senescence inSaccharomyces cerevisiae
Saccharomyces cerevisiae POL2 encodes the catalytic subunit of DNA polymerase ε. This study investigates the cellular functions performed by the polymerase domain of Pol2p and its role in DNAExpand
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Structure and function of the fourth subunit (Dpb4p) of DNA polymerase ε in Saccharomyces cerevisiae
DNA polymerase epsilon (Polepsilon) of Saccharomyces cerevisiae is purified as a complex of four polypeptides with molecular masses of >250, 80, 34 (and 31) and 29 kDa as determined by SDS-PAGE. TheExpand
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Fidelity of DNA Polymerase ε Holoenzyme from Budding YeastSaccharomyces cerevisiae *
DNA polymerases δ and ε (pol δ and ε) are the major replicative polymerases and possess 3′-5′ proofreading exonuclease activities that correct errors arising during DNA replication in the yeastExpand
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