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Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.
TLDR
Observations strongly suggest that Ste11 serves as a key transcription factor for sexual development. Expand
Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos
TLDR
It is shown that small GTPases have sequential and crucial functions in this process of establishment of cell polarity, and suggests that a local change in the function of ECT-2 and RHO-1 links the centrosomal polarity cue with the polarization of the cell cortex. Expand
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
TLDR
A large-scale inactivation of the expressed genes in the nematode Caenorhabditis elegans is reported, establishing a high-throughput "RNAi-by-soaking" methodology and identifying 24 genes that might play important roles in germline development. Expand
Type II Myosin Heavy Chain Encoded by the myo2 Gene Composes the Contractile Ring during Cytokinesis in Schizosaccharomyces pombe
TLDR
Genetic evidence suggested that the acto–myosin system may interact with the Ras pathway, which regulates mating and the maintenance of cell morphology in S. pombe. Expand
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.
TLDR
It is proposed that the RZZ complex can inhibit the formation of load-bearing attachments and that this activity is normally controlled by dynein/dynactin localized via SPDL-1, which could coordinate the hand-off from initial weak dyne in-mediated lateral attachments, which help orient kinetochores and enhance their ability to capture microtubules, to strong end-coupled attachments that drive chromosome segregation. Expand
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
TLDR
Analysis employing sex-determination mutants indicated that the daz-1 function was required for meiosis of female germline regardless of the sex of the soma, unlike other DAZ family members so far reported, it is dispensable for male meiosis. Expand
PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans
TLDR
PGL proteins act as scaffolds that recruit RNPs during C. elegans germ granule formation, and are involved in the formation of germ granules in the elegans genome. Expand
Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure
TLDR
It is reported that homologues of the mammalian Arp2/3 complex and N-WASP in Caenorhabditis elegans play an important role in hypodermal cell migration during morphogenesis, a process known as ventral enclosure. Expand
EGG-3 Regulates Cell-Surface and Cortex Rearrangements during Egg Activation in Caenorhabditis elegans
TLDR
Caenorhabditis elegans EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition. Expand
Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21.
TLDR
SCC-1/COH-2 and the homologs of Scc3, Smc1, and Smc3 facilitate mitotic chromosome segregation during the development, presumably by forming a cohesin complex, whereas COH-1 seems to play a role important for development but unrelated to mitosis. Expand
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