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A gene atlas of the mouse and human protein-encoding transcriptomes.
The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on aExpand
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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling toExpand
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Large-scale analysis of the human and mouse transcriptomes
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experimentsExpand
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BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources
Online gene annotation resources are indispensable for analysis of genomics data. However, the landscape of these online resources is highly fragmented, and scientists often visit dozens of theseExpand
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Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.
Detection, treatment, and prediction of outcome for men with prostate cancer increasingly depend on a molecular understanding of tumor development and behavior. We characterized primary prostateExpand
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Molecular classification of human carcinomas by use of gene expression signatures.
Classification of human tumors according to their primary anatomical site of origin is fundamental for the optimal treatment of patients with cancer. Here we describe the use of large-scale RNAExpand
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Genomic analysis of the host response to hepatitis C virus infection
We have examined the progression of hepatitis C virus (HCV) infections by gene expression analysis of liver biopsies in acutely infected chimpanzees that developed persistent infection, transientExpand
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Expression analysis of G Protein-Coupled Receptors in mouse macrophages
BackgroundMonocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic micro-arrayExpand
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Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of theseExpand
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Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.
Hippo signaling represents a tumor suppressor pathway that regulates organ size and tumorigenesis through phosphorylation and inhibition of the transcription coactivator YAP. Here, we show that serumExpand
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