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Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus
Abstract As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge Plakortis aff.Expand
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11-Deoxyfistularin-3, a new cytotoxic metabolite from the caribbean sponge Aplysina fistularis insularis.
11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean spongeExpand
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Composition and cytotoxic activity of essential oils from Croton matourensis and Croton micans from Venezuela.
The chemical composition and cytotoxic activity of the essential oils extracted from leaves of Croton matourensis and flowers and leaves of Croton micans were investigated. GC-FID and GC-MS analysisExpand
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Pharmacological properties of thalidomide and its analogues.
Thalidomide and its immunomodulatory imide drugs (IMiDs) analogues CC-5013 (Revlimid, Lenalidomide) and CC-4047 (Actimid, Pomalidomide) have been used as anti-inflammatory and anticancerous drugs inExpand
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Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities
The phytochemical investigation of Muehlenbeckia tamnifolia, collected in Loja-Ecuador, led to the isolation of nine known compounds identified as: lupeol acetate (1); cis-p-coumaric acid (2); lupeolExpand
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Gliclazide treatment of streptozotocin diabetic rats restores GLUT4 protein content and basal glucose uptake in skeletal muscle.
This study examined whether the treatment of streptozotocin (STZ)-diabetic rats with gliclazide (5 mg/kg body weight twice daily orally) increases muscle glucose uptake. Rats were treated (group G, nExpand
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Cytotoxic and proapoptotic activity of ent-16β-17α-dihydroxykaurane on human mammary carcinoma cell line MCF-7
Abstract Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16β-17α-dihydroxykaurane), compound isolated from Croton malambo barks, on malignant cell growth. When MCF-7Expand
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The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
PurposeIn search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified from a marine sponge AgelasExpand
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Three new Glutarimide Alkaloids from Croton Cuneatus
Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along withExpand
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Biflavonoids from Podocalyx loranthoides.
Analysis of the ethyl acetate extract of the aerials parts of Podocalyx loranthoides led to the isolation of I 7, II 4'-dimethylamentoflavone (1) and II 4'-methylamentoflavone (2). Compound (1) gaveExpand
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