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Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.
Gliomas are the most common primary brain tumors with heterogeneous morphology and variable prognosis. Treatment decisions in patients rely mainly on histologic classification and clinicalExpand
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Inflammatory conditions affect gene expression and function of human adipose tissue‐derived mesenchymal stem cells
There is emerging interest in the application of mesenchymal stem cells (MSC) for the prevention and treatment of autoimmune diseases, graft‐versus‐host disease and allograft rejection. It is,Expand
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SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma
Further understanding of the molecular biology and pathogenesis of hepatocellular carcinoma (HCC) is crucial for future therapeutic development. SMAD4, recognized as an important tumor suppressor, isExpand
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Discriminating somatic and germline mutations in tumor DNA samples without matching normals.
Tumor analyses commonly employ a correction with a matched normal (MN), a sample from healthy tissue of the same individual, in order to distinguish germline mutations from somatic mutations. SinceExpand
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XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination.
Repair of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important not only for repair of spontaneous breaks but also for breaks induced in developing lymphocytesExpand
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Estrogen and androgen regulation of sex hormone binding globulin secretion by a human liver cell line
Both estrogens and androgens have been shown to stimulate sex hormone binding globulin (SHBG) secretion in vitro in the hepatocellular carcinoma cell line, Hep G2, in contrast to the expectedExpand
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Mobilization of hepatic mesenchymal stem cells from human liver grafts.
Extensive studies have demonstrated the potential applications of bone marrow-derived mesenchymal stem cells (BM-MSCs) as regenerative or immunosuppressive treatments in the setting of organExpand
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Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study
BackgroundEndothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functionalExpand
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Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults
Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and classExpand
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CGtag: complete genomics toolkit and annotation in a cloud-based Galaxy
BackgroundComplete Genomics provides an open-source suite of command-line tools for the analysis of their CG-formatted mapped sequencing files. Determination of; for example, the functional impact ofExpand
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