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- Publications
- Influence
Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot
- H. Cordell, A. Töpf, +34 authors J. Goodship
- Biology, Medicine
- Human molecular genetics
- 7 January 2013
We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of Fallot (TOF), using a northern European discovery set of 835 cases and 5159 controls. A region on… Expand
Physical activity levels in adults with congenital heart disease
- J. Dua, A. Cooper, K. Fox, A. Stuart
- Medicine, Psychology
- European journal of cardiovascular prevention and…
- 1 April 2007
Background Regular physical activity is associated with many health benefits in patients with cardiac disease. Advances in treatment have resulted in an increasing population of adults with… Expand
Systematic survey of variants in TBX1 in non-syndromic tetralogy of Fallot identifies a novel 57 base pair deletion that reduces transcriptional activity but finds no evidence for association with…
- H. Griffin, A. Töpf, +12 authors J. Goodship
- Medicine
- Heart
- 11 October 2010
Background Tetralogy of Fallot (TOF) is common in individuals with hemizygous deletions of chromosome 22q11.2 that remove the cardiac transcription factor TBX1. Objective To assess the contribution… Expand
Medical treatment of Marfan syndrome: a time for change
- A. Williams, S. Davies, A. Stuart, D. G. Wilson, A. Fraser
- Medicine
- Heart
- 4 October 2007
It is accepted practice to prescribe β-blockers in order to retard aortic dilatation and prevent aortic dissection and rupture in patients with Marfan syndrome. A critical review of the published… Expand
Current trends in the management of heart disease in pregnancy.
- S. Curtis, Joanna Marsden-Williams, +4 authors A. Stuart
- Medicine
- International journal of cardiology
- 20 March 2009
BACKGROUND
The management of heart disease in pregnancy is highly specialized. Guidelines are based on observational studies. This paper describes our experience of these patients, including adverse… Expand
Functionally Significant, Rare Transcription Factor Variants in Tetralogy of Fallot
- A. Töpf, H. Griffin, +10 authors J. Goodship
- Biology, Medicine
- PloS one
- 5 August 2014
Objective Rare variants in certain transcription factors involved in cardiac development cause Mendelian forms of congenital heart disease. The purpose of this study was to systematically assess the… Expand
Emerging therapeutic targets in the short QT syndrome
- J. Hancox, Dominic G. Whittaker, Chunyun Du, A. Stuart, H. Zhang
- Medicine
- Expert opinion on therapeutic targets
- 4 May 2018
ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of sudden death. Implantable… Expand
Association Between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7697 Cases and 13 125 Controls
- Chrysovalanto Mamasoula, R. Prentice, +39 authors B. Keavney
- Medicine, Biology
- Circulation. Cardiovascular genetics
- 22 July 2013
Background—Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. Methods and Results—We compared… Expand
Outcome in congenital heart disease
Summary Largely as a result of advances in cardiac surgery, at least 85% of children with children with congenital heart disease can expect to survive to adult life. As a consequence, there will soon… Expand
Kendall's Tau
- A. Stuart
- Computer Science
- 15 October 2004
TLDR