Iron Acquisition and Regulation in Campylobacter jejuni
- Kiran S Palyada, D. Threadgill, A. Stintzi
- BiologyJournal of Bacteriology
- 15 July 2004
The complex response of C. jejuni to iron availability is documents, the genetic network between the Fur and iron regulons is described, and insight is provided regarding the role of iron in C.Jejuni colonization in vivo.
Gene Expression Profile of Campylobacter jejuni in Response to Growth Temperature Variation
- A. Stintzi
- BiologyJournal of Bacteriology
- 15 March 2003
New insights are provided into the primary response of C. jejuni to surmount a sudden temperature upshift, allowing the bacterium to survive and adapt its transcriptome to a new steady state.
Use of siderophores to type pseudomonads: the three Pseudomonas aeruginosa pyoverdine systems.
- J. Meyer, A. Stintzi, H. Budzikiewicz
- Biology, MedicineMicrobiology
- 1997
Eighty-eight Pseudomonas aeruginosa isolates, most of them from the Collection of Bacterial Strains of the Institut Pasteur, Paris, were analysed for their pyoverdine-mediated iron incorporation…
l-Fucose utilization provides Campylobacter jejuni with a competitive advantage
- M. Stahl, L. Friis, A. Stintzi
- BiologyProceedings of the National Academy of Sciences
- 11 April 2011
This work identifies a previously unrecorded metabolic pathway in select strains of C. jejuni associated with a virulent lifestyle that is deficient in fucose uptake and demonstrate a competitive disadvantage when colonizing the piglet model of human disease, which is not paralleled in the colonization of poultry.
Pyoverdin is essential for virulence of Pseudomonas aeruginosa
- J. Meyer, A. Neely, A. Stintzi, C. Georges, I. A. Holder
- Biology, MedicineInfection and Immunity
- 1 February 1996
It is suggested that pyoverdin competes directly with transferrin for iron and that it is an essential element for in vivo iron gathering and virulence expression in P. aeruginosa.
Identification of Campylobacter jejuni Genes Involved in the Response to Acidic pH and Stomach Transit
- A. Reid, R. Pandey, Kiran S Palyada, H. Naikare, A. Stintzi
- BiologyApplied and Environmental Microbiology
- 11 January 2008
To understand how C. jejuni modulates gene expression in response to acid shock in vitro and to correlate this with gene expression profiles of C.Jejuni as it transits through the host stomach, a transcriptional profile was obtained after the organism was exposed to in vivo and in vivo acid shock.
Major Role for FeoB in Campylobacter jejuni Ferrous Iron Acquisition, Gut Colonization, and Intracellular Survival
- H. Naikare, Kiran S Palyada, R. Panciera, D. Marlow, A. Stintzi
- BiologyInfection and Immunity
- 1 October 2006
It is demonstrated that FeoB-mediated ferrous iron acquisition contributes significantly to colonization of the gastrointestinal tract during both commensal and infectious relationship, and thus it plays an important role in Campylobacter pathogenesis.
Identification of the Iron-Responsive Genes of Neisseria gonorrhoeae by Microarray Analysis in Defined Medium
- T. Ducey, M. Carson, Joshua Orvis, A. Stintzi, D. Dyer
- BiologyJournal of Bacteriology
- 1 July 2005
A pan-Neisseria microarray was used to examine genes regulated in Neisseria gonorrhoeae in response to iron availability in defined medium, suggesting a regulatory cascade where Fur indirectly controls gene expression by affecting the transcription of three secondary regulators.
Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: lasR/lasI mutants exhibit reduced pyoverdine biosynthesis.
- A. Stintzi, K. Evans, J. Meyer, K. Poole
- BiologyFEMS Microbiology Letters
- 15 September 1998
This represents the first report of quorum-sensing regulation of siderophore production in bacteria and highlights the fact that cell density, while not an essential signal for pyoverdine expression, does enhance production of this siderophile.
Microbial iron transport via a siderophore shuttle: a membrane ion transport paradigm.
- A. Stintzi, C. Barnés, J. Xu, K. Raymond
- Biology, Environmental ScienceProceedings of the National Academy of Sciences…
- 26 September 2000
It is shown that the siderophore and Fe(3+) enter the bacterium together, a ligand exchange step occurs in the course of the transport, and a redox process is not involved in iron exchange.
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