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Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
Serum albumin (SA) is the most abundant plasma protein in mammals. SA is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range ofExpand
Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.
Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent, and interactive binding of zinc and long-chain fatty acids to albumin may have physiological implications. Expand
Interdomain zinc site on human albumin
Analysis of x-ray crystal structures of human albumin suggests that fatty acid binding to site 2 triggers a spring-lock mechanism, which disengages the upper and lower halves of the metal site, which provides a possible mechanism whereby fatty acids could influence the transport and delivery of zinc in blood. Expand
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.
It is shown here that PHOSPHO1 exhibits high specific activities toward phosphoethanolamine (PEA) and phosphocholine (PCho), which provides a novel mechanism for the generation of P(i) in mineralizing cells from PEA and PCho. Expand
GPR39: a Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions
GPR39 is now emerging as an important transducer of autocrine and paracrine Zn2+ signals, impacting upon cellular processes such as insulin secretion, gastric emptying, neurotransmission and epithelial repair. Expand
Retention and Silencing of Prepro-GnRH-II and Type II GnRH Receptor Genes in Mammals
Retention of large sections of each gene in most mammalian genomes suggests that mammalian ancestors had a functional GnRH-II system, and significant variation in the DNA sequence conservation and functional status of each genes, even between closely related species. Expand
Role of Tyr84 in controlling the reactivity of Cys34 of human albumin
The tethering of the two loops containing Tyr84 and Cys34 not only appears to control the redox potential and accessibility of Cys 34, but also triggers the transmission of information about the state of CYS34 throughout domain I, and to the domainI/II interface. Expand
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.
Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation.Expand
Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis.
Results imply expression of LHR splice variants is regulated in the human CL, and during functional luteolysis a truncated variant could modulate the cell surface expression and activity of full-length LHR. Expand
Antiproliferative Effects of GnRH Agonists: Prospects and Problems for Cancer Therapy
Data on the effects of GnRH agonists on cell proliferation and apoptosis is reviewed, and hypotheses for investigation are put forward to determine whether the GnRH receptor acts as a tumor suppressor in neuroendocrine or epithelial cells. Expand