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  • Influence
From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics.
TLDR
The results point to cocaine's anesthetic properties as the dominant mechanism of interaction in the fish: upon entry through the fish skin and gills, it first acts on peripheral nerves rapidly overriding any potential stimulatory response in the brain.
Influence of Different Sewer Biofilms on Transformation Rates of Drugs.
TLDR
The authors' transformation rates include careful quantification of uncertainty and can be used to identify situations in which specific compounds are not stable and improve accuracy and uncertainty estimates of drug consumption when applied to the back-calculation.
Systematic investigation of the incorporation mechanisms of zolpidem in fingernails.
TLDR
It can be concluded that fingernail clippings may represent a useful alternative and/or complementary matrix in cases of, for example, drug-facilitated sexual assault or monitoring of constant consumption behavior.
Liquid chromatography, in combination with a quadrupole time-of-flight instrument (LC QTOF), with sequential window acquisition of all theoretical fragment-ion spectra (SWATH) acquisition: systematic
TLDR
Screening results of 382 authentic forensic cases revealed that SWATH's detection rate was superior to IDA, which failed to trigger relevant compounds, and the detection rate of IDA compared to SWATH was investigated in a forced coelution experiment.
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects
TLDR
The present pharmacokinetic data are important for the evaluation of clinical study findings and the interpretation of LSD intoxication, with moderate counterclockwise hysteresis.
Single hair analysis of small molecules using MALDI-triple quadrupole MS imaging and LC-MS/MS: investigations on opportunities and pitfalls.
TLDR
MALDI-MSI and LC-MS/MS segmental single hair analysis showed good correlation, and both are suitable for consumption monitoring of drugs of abuse with a high time resolution.
Time-dependent postmortem redistribution of butyrfentanyl and its metabolites in blood and alternative matrices in a case of butyrfentanyl intoxication.
TLDR
Butyrfentanyl seems to be prone to postmortem redistribution processes and concentrations in forensic death cases should be interpreted with caution.
Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.
TLDR
Untargeted metabolomics proved as a suitable tool for the non-hypothesis driven identification of new GHB markers, however, more studies on actual concentrations, detection windows, and stability will be necessary to assess the suitability of these markers for routine application.
Postmortem distribution and redistribution of MDAI and 2-MAPB in blood and alternative matrices.
TLDR
This is the first study on postmortem redistribution of the new psychoactive substances MDAI and 2-MAPB and more studies covering more cases are necessary to generate universal statements on the PMR with these two NPSs.
Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass
TLDR
In vitro and in vivo phase I and phase II metabolites of butyrfentanyl were elucidated combining liquid chromatography with a qTOF high resolution mass spectrometer and Butyrf fentanyl was shown to undergo extensive metabolism.
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