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Urocortin Protects against Ischemic and Reperfusion Injury via a MAPK-dependent Pathway*
Urocortin (UCN) is a peptide related to hypothalamic corticotrophin-releasing hormone and binds with high affinity to corticotrophin-releasing hormone receptor-2β, which is expressed in the heart. InExpand
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STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis*
The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which STAT-1 mediatesExpand
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Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis*
We show here that exposure of cardiac cells to simulated ischemia results in apoptosis and is accompanied by phosphorylation and increased expression and transcriptional activity of STAT-1.Expand
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Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters
The Bcl-2 family of proteins contains at least 15 members which can have proor anti-apoptotic effects. All share at least one of four Bcl-2 homology domains (BH1 to BH4), and inclusion of differentExpand
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STAT‐1: a novel regulator of apoptosis
Summary.  Extracellular signalling molecules binding to their specific receptors are able to modulate gene expression, leading to changes in development, cell growth and homeostasis. The signalExpand
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Role of the JAK-STAT pathway in myocardial injury.
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still notExpand
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Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury
Background—Apoptosis contributes to cell loss after ischemia/reperfusion injury in the heart. This study describes the time course and level of apoptosis in different cell types in the intact heartExpand
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Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury.
Autophagy is known to be a feature of cardiomyopathies and chronic ischaemia. Here we demonstrate that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adultExpand
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Epigallocatechin‐3‐gallate inhibits STAT‐1 activation and protects cardiac myocytes from ischemia/reperfusion‐ induced apoptosis
We have previously demonstrated that STAT‐1 plays a critical role in promoting apoptotic cell death in cardiac myocytes following ischemia/reperfusion (I/R) injury. Epigallocatechin‐3‐gallate (EGCG),Expand
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Opposing actions of STAT-1 and STAT-3
The signal transducers and activators of transcription (STATs) are a family of transcription factors, which were originally identified on the basis of their ability to transduce a signal from aExpand
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