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Fever and hypothermia in systemic inflammation: recent discoveries and revisions.
Systemic inflammation is accompanied by changes in body temperature, either fever or hypothermia. Over the past decade, the rat and mouse have become the predominant animal models, and newExpand
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The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not
The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans. This undesirableExpand
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Nonthermal Activation of Transient Receptor Potential Vanilloid-1 Channels in Abdominal Viscera Tonically Inhibits Autonomic Cold-Defense Effectors
An involvement of the transient receptor potential vanilloid (TRPV) 1 channel in the regulation of body temperature (Tb) has not been established decisively. To provide decisive evidence for such anExpand
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Hypoxia-induced anapyrexia: implications and putative mediators.
Hypoxia elicits an array of compensatory responses in animals ranging from protozoa to mammals. Central among these responses is anapyrexia, the regulated decrease of body temperature. The importanceExpand
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Cellular and Molecular Bases of the Initiation of Fever
All phases of lipopolysaccharide (LPS)-induced fever are mediated by prostaglandin (PG) E2. It is known that the second febrile phase (which starts at ~1.5 h post-LPS) and subsequent phases areExpand
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Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature.
Most published studies of thermoregulatory responses of mice to LPS involved a stressful injection of LPS, were run at a poorly controlled and often subneutral ambient temperature (T(a)), and paidExpand
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Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation.
The natural switch from fever to hypothermia observed in the most severe cases of systemic inflammation is a phenomenon that continues to puzzle clinicians and scientists. The present study was theExpand
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Thermoregulatory Phenotype of the Trpv1 Knockout Mouse: Thermoeffector Dysbalance with Hyperkinesis
This study aimed at determining the thermoregulatory phenotype of mice lacking transient receptor potential vanilloid-1 (TRPV1) channels. We used Trpv1 knockout (KO) mice and their geneticallyExpand
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Lipopolysaccharide fever is initiated via a capsaicin‐sensitive mechanism independent of the subtype‐1 vanilloid receptor
As pretreatment with intraperitoneal capsaicin (8‐methyl‐N‐vanillyl‐6‐nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel‐vanilloid receptorExpand
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Neural Substrate of Cold-Seeking Behavior in Endotoxin Shock
Systemic inflammation is a leading cause of hospital death. Mild systemic inflammation is accompanied by warmth-seeking behavior (and fever), whereas severe inflammation is associated withExpand
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