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Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism
Summary The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate,Expand
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Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impactExpand
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A trade off between mlo resistance to powdery mildew and increased susceptibility of barley to a newly important disease, Ramularia leaf spot
Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, is a serious, recently emerged disease of barley in Europe and other temperate regions. This study investigated the trade offExpand
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Discovery of a Short‐Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid
Plant monoterpene indole alkaloids, a large class of natural products, derive from the biosynthetic intermediate strictosidine aglycone. Strictosidine aglycone, which can exist as a variety ofExpand
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Seed comparative genomics in three coffee species identify desiccation tolerance mechanisms in intermediate seeds
Abstract In contrast to desiccation-tolerant ‘orthodox’ seeds, so-called ‘intermediate’ seeds cannot survive complete drying and are short-lived. All species of the genus Coffea produce intermediateExpand
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Interactions between apparently ‘primary’ weather-driven hazards and their cost
A statistical analysis of the largest weather-driven hazards in the UK contradicts the typical view that each predominates in distinct events that do not interact with those of other hazard typesExpand
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Investigation into the Production of a Cellulytic Saccharomyces – Identification of a High Cellulytic Trichoderma spp. for Gene Selection
The isolation and identification of a hyper-cellulytic fungus for cellulase gene selection was carried out as the initial stages in the production of a recombinant micro-organism. This would beExpand
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Synthetic biology for production of plant-derived alkaloids
The medicinal plant Madagascar periwinkle (Catharanthus roseus) produces a large palette of Monoterpenoid Indole Alkaloids (MIAs). These compounds originate from the universal precursor strictosidineExpand
Duplication of alcohol dehydrogenases unlocks the chemical diversity of the medicinal plant Catharanthus roseus
This thesis details the discovery and characterisation of biosynthetic enzymes implicated in the monoterpene indole alkaloid (MIA) pathway of the medicinal plant Catharanthus roseus. The MIA pathwayExpand