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Assessment of the chromatographic lipophilicity of eight cephalosporins on different stationary phases
ABSTRACT The retention behaviors were investigated for a series of eight cephalosporins in thin‐layer chromatography (TLC) using stationary phases of RP‐2, RP‐8, RP‐18, –NH2, –DIOL, and –CNExpand
Lipophilicity of thiobarbiturates determined by TLC.
Lipophilicty of 29 thiobarbituric acid derivatives were assessed by reversed-phase thin-layer chromatography using methanol: water mixtures as a mobile phase. A linear relationship was found betweenExpand
Synthesis of Thio Derivatives of Phenobarbital and Its N-Methyl Derivatives
Differently substituted thio derivatives of phenobarbital and its N-mono- and N,N'-dimethyl derivatives were obtained by thionation of respective substrates with Lawesson's reagent. The structure ofExpand
The influence of sulfur substituents on the molecular geometry and packing of thio derivatives of N-methylphenobarbital.
The room-temperature crystal structures of four new thio derivatives of N-methylphenobarbital [systematic name: 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione], C(13)H(14)N(2)O(3), areExpand
Hydrolysis of 2,4-dithiophenobarbital.
Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2-12 was investigated at 40 and 60 degrees C using UV spectrophotometry. The values of reaction order, rate constants, pKa1 and pKa2Expand
Stability of 2-thiophenobarbital and its N-methyl derivatives in the presence of beta-cyclodextrin.
The rates of hydrolysis of thiophenobarbital and its N-mono- and N,N'-dimethyl-derivatives were determined under different conditions of pH and temperature using UV spectroscopy. They were comparedExpand
Kinetics of Hydrolysis of N-Methyl-2,4-dithiophenobarbital
The rate of hydrolytic degradation of N-methyl-2,4-dithiophenobarbital by spectrophotometric and separation methods was studied. The rate constants, order of reaction, activation energy, and pKaExpand