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Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
AIMS In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK₁) is thought to set the negative and stable resting membrane potential, and contributes to action potentialExpand
Different Inward and Outward Conduction Mechanisms in NaVMs Suggested by Molecular Dynamics Simulations
We use molecular dynamics (MD) simulations with an applied membrane potential to investigate the ion flux of bacterial sodium channel NaVMs. Expand
Surprises from an unusual CLC homolog.
The chloride channel (CLC) family is distinctive in that some members are Cl(-) ion channels and others are Cl(-)/H(+) antiporters. The molecular mechanism that couples H(+) and Cl(-) transport inExpand
Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond
Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. Consumption of grayanotoxin containing leaves, flowers or secondary products as honeyExpand
New potential binding determinant for hERG channel inhibitors
Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K+ current (IKr) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition byExpand
Molecular Determinants for Activation of Human Ether-à-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide
Human ether-à-go-go-related gene 1 (hERG1) channels mediate repolarization of cardiac action potentials. Inherited long QT syndrome (LQTS) caused by loss-of-function mutations, or unintended blockadeExpand
Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of CaV1.2: a cooperative gating model
  • S. Beyl, K. Depil, +4 authors S. Hering
  • Chemistry, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 2 September 2012
Voltage sensors trigger the closed–open transitions in the pore of voltage-gated ion channels. To probe the transmission of voltage sensor signalling to the channel pore of CaV1.2, we investigatedExpand
Distinct interactions of Na+ and Ca2+ ions with the selectivity filter of the bacterial sodium channel Na(V)Ab.
Rapid and selective ion transport is essential for the generation and regulation of electrical signaling pathways in living organisms. In this study, we use molecular dynamics simulations and freeExpand
Timothy Mutation Disrupts the Link between Activation and Inactivation in CaV1.2 Protein*
The Timothy syndrome mutations G402S and G406R abolish inactivation of CaV1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation onExpand
Computer simulations of structure-activity relationships for HERG channel blockers.
The hERG potassium channel is of major pharmaceutical importance, and its blockade by various compounds, potentially causing serious cardiac side effects, is a major problem in drug development.Expand