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Characteristics of intestinal dendritic cells in inflammatory bowel diseases.
BACKGROUND & AIMS Dendritic cells (DCs) recognize and respond to microbial structures using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs are pivotal inExpand
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Modulation of human dendritic cell phenotype and function by probiotic bacteria
Background: “Probiotic” bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells,Expand
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Mechanisms of action of probiotics: Recent advances
&NA; The intestinal microbiota plays a fundamental role in maintaining immune homeostasis. In controlled clinical trials probiotic bacteria have demonstrated a benefit in treating gastrointestinalExpand
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Migration and Maturation of Human Colonic Dendritic Cells
Dendritic cells (DC) in the colon may regulate intestinal immunity but remain poorly characterized. In this study a CD11c+HLA-DR+lin− (CD3−CD14−CD16−CD19−CD34−) population has been identified by flowExpand
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Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn’s disease
Background and aims: The intestinal microbiota play a pivotal role in the inflammation associated with Crohn’s disease through their interaction with the mucosal immune system. Some bifidobacteriaExpand
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Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease
Introduction The commensal intestinal microbiota drive the inflammation associated with Crohn's disease. However, bacteria such as bifidobacteria and Faecalibacterium prausnitzii appear to beExpand
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Murine dendritic cells internalize Leishmania major promastigotes, produce IL‐12 p40 and stimulate primary T cell proliferation in vitro
Metacyclic Leishmania promastigotes (PM), transmitted by sand‐fly bite, are likely to interact initially with cells of the dendritic cell (DC) lineage(s) in the epidermis or dermis. EpidermalExpand
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Intestinal dendritic cells: Their role in bacterial recognition, lymphocyte homing, and intestinal inflammation
&NA; Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity.Expand
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Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis
Background: In ulcerative colitis (UC) gut bacteria drive inflammation. Bacterial recognition and T‐cell responses are shaped by intestinal dendritic cells (DCs); therapeutic effects of probioticExpand
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The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
Dendritic cells are antigen presenting cells that are likely to be pivotal in the balance between tolerance and active immunity to commensal microorganisms that is fundamental to inflammatoryExpand
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